MicroRNA 320, an Anti-Oncogene Target miRNA for Cancer Therapy

MicroRNAs are a set of highly conserved non-coding RNAs that control gene expression at the post-transcriptional/translational levels by binding to the 3 '-UTR of diverse target genes. Increasing evidence indicates that miRNAs not only play a vital role in many biological processes, but they are also frequently deregulated in pathological conditions, including cancer. The miR-320 family is one of many tumor suppressor families and is composed of five members, which has been demonstrated to be related to the repression of epithelial-mesenchymal transition (EMT) inhibition, cell proliferation, and apoptosis. Moreover, this family has been shown to regulate drug resistance, and act as a potential biomarker for the diagnosis, prognosis, and prediction of cancer. In this review, we summarized recent research with reference to the tumor suppressor function of miR-320 and the regulation mechanisms of miR-320 expression. The collected evidence shown here supports that miR-320 may act as a novel biomarker for cancer prognosis and therapeutic response to cancer treatment.

Automated summary

MicroRNAs, specifically the miR-320 family, play a crucial role in regulating gene expression and have been identified as tumor suppressors. Their functions in cancer research extend to inhibition of epithelial-mesenchymal transition, cell proliferation, and apoptosis, while also serving as potential biomarkers for cancer diagnosis and prognosis.