Journal
BIOMARKER RESEARCH
Volume 9, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s40364-021-00323-7
Keywords
Wnt signaling; beta-catenin; Epigenetic modification; Tumor microenvironment; Drug development
Categories
Funding
- Xiang'an Hospital [PM202012220001]
- China National Natural Science Foundation [81772994, 81302068]
- China National High Technology Research and Development Program (863-Program) [2014AA020541]
- International Collaborative Project of Fujian Province [2017I0014]
- Program for the Top Young Innovative Talents of Fujian Province [2016RCLKC]
Ask authors/readers for more resources
Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.
Wnt signaling was initially recognized to be vital for tissue development and homeostasis maintenance. Further studies revealed that this pathway is also important for tumorigenesis and progression. Abnormal expression of signaling components through gene mutation or epigenetic regulation is closely associated with tumor progression and poor prognosis in several tissues. Additionally, Wnt signaling also influences the tumor microenvironment and immune response. Some strategies and drugs have been proposed to target this pathway, such as blocking receptors/ligands, targeting intracellular molecules, beta-catenin/TCF4 complex and its downstream target genes, or tumor microenvironment and immune response. Here we discuss the roles of these components in Wnt signaling pathway in tumorigenesis and cancer progression, the underlying mechanisms that is responsible for the activation of Wnt signaling, and a series of drugs targeting the Wnt pathway provide multiple therapeutic values. Although some of these drugs exhibit exciting anti-cancer effect, clinical trials and systematic evaluation should be strictly performed along with multiple-omics technology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available