Journal
CURRENT OPINION IN ELECTROCHEMISTRY
Volume 31, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.coelec.2021.100837
Keywords
Alzheimer's disease (AD); Amyloid beta (A beta); Fibrilization; Aggregation; Adsorption; Oxidation; Voltammetry; AD biomarker
Funding
- FEDER funds through the program COMPETEePrograma Operacional Factores de Competitividade
- national funds through Fundacao para a Ciencia e a Tecnologia [UIDB/00285/2020]
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This review discusses recent advances in the direct electrochemical detection of A beta's redox mechanisms, fibrilization, and interaction with metal ions based on the oxidation peaks of A beta's Y, H, and M amino acid residues.
Alzheimer disease is a progressive age-related neurodegenerative disorder estimated to affect up to 107 million people by 2050, its pathology is associated with the dysfunction of the amyloid beta (A beta) peptide mechanism, among others. Electrochemical methods were successfully applied for A beta electrochemical characterisation and have received increased attention in Ab research. This review discusses the recent advances on the direct electrochemical detection of A beta redox mechanisms, fibrilization and interaction with metal ions based on the electrochemical detection of the A beta's Y, H and M amino acid residues oxidation peaks.
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