Journal
NPJ BREAST CANCER
Volume 7, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41523-021-00287-9
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Funding
- Exelixis
- Bristol-Myers Squibb
- National Institutes of Health [T32CA009172]
- Rob and Karen Hale Distinguished Chair in Surgical Oncology
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This single-arm phase II study evaluating the combination of cabozantinib and nivolumab in metastatic triple-negative breast cancer did not show significant efficacy, and was stopped early due to toxicity. High levels of tumor immunosuppression were observed, as indicated by immunostaining, genomic, and proteomic studies.
This single-arm phase II study investigated the efficacy and safety of cabozantinib combined with nivolumab in metastatic triple-negative breast cancer (mTNBC). The primary endpoint was objective response rate (ORR) by RECIST 1.1. Biopsies at baseline and after cycle 1 were analyzed for tumor-infiltrating lymphocytes (TILs), PD-L1, and whole-exome and transcriptome sequencing. Only 1/18 patients achieved a partial response (ORR 6%), and the trial was stopped early. Toxicity led to cabozantinib dose reduction in 50% of patients. One patient had a PD-L1-positive tumor, and three patients had TILs > 10%. The responding patient had a PD-L1-negative tumor with low tumor mutational burden but high TILs and enriched immune gene expression. High pretreatment levels of plasma immunosuppressive cytokines, chemokines, and immune checkpoint molecules were associated with rapid progression. Although this study did not meet its primary endpoint, immunostaining, genomic, and proteomic studies indicated a high degree of tumor immunosuppression in this mTNBC cohort.
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