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Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease
Lorraine V. Kalia et al.
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Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein
Cristine Betzer et al.
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Role of α-Synuclein in Inducing Innate and Adaptive Immunity in Parkinson Disease
Heather E. Allen Reish et al.
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Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
Ariadna Recasens et al.
ANNALS OF NEUROLOGY (2014)
Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines
Beatriz Alvarez-Castelao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity
Oldriska Chutna et al.
HUMAN MOLECULAR GENETICS (2014)
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
Anne-Laure Mahul-Mellier et al.
HUMAN MOLECULAR GENETICS (2014)
Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies
Jose Bras et al.
HUMAN MOLECULAR GENETICS (2014)
Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
Karina J. Vargas et al.
JOURNAL OF NEUROSCIENCE (2014)
ESCRT-mediated Uptake and Degradation of Brain-targeted α-synuclein Single Chain Antibody Attenuates Neuronal Degeneration In Vivo
Brian Spencer et al.
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Alpha-Synuclein in the Appendiceal Mucosa of Neurologically Intact Subjects
Madison T. Gray et al.
MOVEMENT DISORDERS (2014)
Neuropathology of Multiple System Atrophy: New Thoughts About Pathogenesis
Kurt A. Jellinger
MOVEMENT DISORDERS (2014)
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
Petra Pasanen et al.
NEUROBIOLOGY OF AGING (2014)
Skin nerve α-synuclein deposits A biomarker for idiopathic Parkinson disease
Vincenzo Donadio et al.
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Submandibular gland needle biopsy for the diagnosis of Parkinson disease
Charles H. Adler et al.
NEUROLOGY (2014)
Low clinical diagnostic accuracy of early vs advanced Parkinson disease Clinicopathologic study
Charles H. Adler et al.
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Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?
Katerina Markopoulou et al.
PARKINSONISM & RELATED DISORDERS (2014)
A Generic Method for Design of Oligomer-Specific Antibodies
Kristoffer Brannstrom et al.
PLOS ONE (2014)
Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation
Luis Fonseca-Ornelas et al.
NATURE COMMUNICATIONS (2014)
Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry
John F. Kellie et al.
SCIENTIFIC REPORTS (2014)
Protein phosphorylation in neurodegeneration: friend or foe?
Sandra Tenreiro et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)
Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
Mathilde Chivet et al.
JOURNAL OF EXTRACELLULAR VESICLES (2014)
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?
Aoife P. Kiely et al.
ACTA NEUROPATHOLOGICA (2013)
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
Jens Wagner et al.
ACTA NEUROPATHOLOGICA (2013)
G51D α-Synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
Suzanne Lesage et al.
ANNALS OF NEUROLOGY (2013)
One-pot total chemical synthesis of human α-synuclein
Bruno Fauvet et al.
CHEMICAL COMMUNICATIONS (2013)
Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages
Tim Guilliams et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Activity-dependent secretion of alpha-synuclein by enteric neurons
Sebastien Paillusson et al.
JOURNAL OF NEUROCHEMISTRY (2013)
Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation
Therese Fagerqvist et al.
JOURNAL OF NEUROCHEMISTRY (2013)
Animal Models of Parkinson's Disease: Limits and Relevance to Neuroprotection Studies
Erwan Bezard et al.
MOVEMENT DISORDERS (2013)
Alpha-synuclein gene duplication: Marked intrafamilial variability in two novel pedigrees
Antonio E. Elia et al.
MOVEMENT DISORDERS (2013)
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
Silke Appel-Cresswell et al.
MOVEMENT DISORDERS (2013)
SNCA: Major genetic modifier of age at onset of Parkinson's disease
Kathrin Brockmann et al.
MOVEMENT DISORDERS (2013)
Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects
Brit Mollenhauer et al.
NEUROSCIENCE LETTERS (2013)
α-Synucleinopathy phenotypes
Heather McCann et al.
PARKINSONISM & RELATED DISORDERS (2013)
Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease
Shyra J. Gardai et al.
PLOS ONE (2013)
Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease
Sang Myun Park et al.
PRION (2013)
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
Mahmood Haj-Yahya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Structural and functional characterization of two alpha-synuclein strains
Luc Bousset et al.
NATURE COMMUNICATIONS (2013)
An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology
Gabor G. Kovacs et al.
ACTA NEUROPATHOLOGICA (2012)
Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients With Dementia and/or Parkinsonian Disorders
Sara Hall et al.
ARCHIVES OF NEUROLOGY (2012)
Identification of Protein Interfaces between α-Synuclein, the Principal Component of Lewy Bodies in Parkinson Disease, and the Molecular Chaperones Human Hsc70 and the Yeast Ssa1p
Virginie Redeker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
Kelvin C. Luk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease
Abid Oueslati et al.
JOURNAL OF NEUROSCIENCE (2012)
Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation
Maria Jose Diogenes et al.
JOURNAL OF NEUROSCIENCE (2012)
Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo
Emanuela Colla et al.
JOURNAL OF NEUROSCIENCE (2012)
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M. Danzer et al.
MOLECULAR NEURODEGENERATION (2012)
The neuropathology, pathophysiology and genetics of multiple system atrophy
Z. Ahmed et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2012)
Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging
Assimina Argyriou et al.
NEUROSCIENCE LETTERS (2012)
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
Randall J. Bateman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study (vol 10, pg 230, 2011)
B. Mollenhauer et al.
LANCET NEUROLOGY (2011)
Glia: Initiators and Progressors of Pathology in Parkinson's Disease
Glenda M. Halliday et al.
MOVEMENT DISORDERS (2011)
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Laura A. Volpicelli-Daley et al.
NEURON (2011)
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study
Brit Mollenhauer et al.
LANCET NEUROLOGY (2011)
SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease
Pablo Garcia-Reitboeck et al.
BRAIN (2010)
PINK1-linked parkinsonism is associated with Lewy body pathology
Lluis Samaranch et al.
BRAIN (2010)
Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins
Jobin Varkey et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Synapsins Differentially Control Dopamine and Serotonin Release
Brian M. Kile et al.
JOURNAL OF NEUROSCIENCE (2010)
Cell-Produced α-Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
Evangelia Emmanouilidou et al.
JOURNAL OF NEUROSCIENCE (2010)
Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits α-Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
Katerina E. Paleologou et al.
JOURNAL OF NEUROSCIENCE (2010)
Production of a monoclonal antibody, against human α-synuclein, in a subpopulation of C57BL/6J mice, presenting a deletion of the α-synuclein locus
Anne-Laure J. Mougenot et al.
JOURNAL OF NEUROSCIENCE METHODS (2010)
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
Venu M. Nemani et al.
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αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
Becket Greten-Harrison et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Jacqueline Burre et al.
SCIENCE (2010)
SNCA Variants Are Associated with Increased Risk for Multiple System Atrophy
Sonja W. Scholz et al.
ANNALS OF NEUROLOGY (2009)
H-1, C-13 and N-15 assignments of a camelid nanobody directed against human alpha-synuclein
Anneleen Vuchelen et al.
BIOMOLECULAR NMR ASSIGNMENTS (2009)
Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
Juliane Neumann et al.
BRAIN (2009)
Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models
Damla Pinar Karpinar et al.
EMBO JOURNAL (2009)
Detecting Morphologically Distinct Oligomeric Forms of α-Synuclein
Sharareh Emadi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells
Christine L. Kragh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Structural Properties of Pore-Forming Oligomers of α-Synuclein
Hai-Young Kim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Genome-wide association study reveals genetic risk underlying Parkinson's disease
Javier Simon-Sanchez et al.
NATURE GENETICS (2009)
Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease
Yan-Jiang Wang et al.
NEUROBIOLOGY OF AGING (2009)
A Swedish family with de novo α-synuclein A53T mutation: Evidence for early cortical dysfunction
Andreas Puschmann et al.
PARKINSONISM & RELATED DISORDERS (2009)
Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration
Haeman Jang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Structural and mechanistic basis behind the inhibitory interaction of PcTS on α-synuclein amyloid fibril formation
Gonzalo R. Lamberto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The progression of pathology in longitudinally followed patients with Parkinson's disease
Glenda Halliday et al.
ACTA NEUROPATHOLOGICA (2008)
Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
Brit Mollenhauer et al.
EXPERIMENTAL NEUROLOGY (2008)
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of α-synuclein
Katerina E. Paleologou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
Jia-Yi Li et al.
NATURE MEDICINE (2008)
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
Jeffrey H. Kordower et al.
NATURE MEDICINE (2008)
Red blood cells are the major source of alpha-synuclein in blood
Robin Barbour et al.
NEURODEGENERATIVE DISEASES (2008)
Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins
C. Schnack et al.
NEUROSCIENCE (2008)
GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein
Clemens R. Scherzer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The phosphorylation state of Ser-129 in human α-synuclein determines neurodegeneration in a rat model of Parkinson disease
Oleg S. Gorbatyuk et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The fold of α-synuclein fibrils
Marcal Vilar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Isolation of a human single chain antibody fragment against oligomeric α-synuclein that inhibits aggregation and prevents α-synuclein-induced toxicity
Sharareh Emadi et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
The Ala53Thr mutation in the α-synuclein gene in a Korean family with Parkinson disease
C-S Ki et al.
CLINICAL GENETICS (2007)
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication
J. Fuchs et al.
NEUROLOGY (2007)
Presynaptic α-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
Michael L. Kramer et al.
JOURNAL OF NEUROSCIENCE (2007)
Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies
Hedieh Barkhordarian et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2006)
Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?
Hilal A. Lashuel et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2006)
Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
Omar M. A. El-Agnaf et al.
FASEB JOURNAL (2006)
α-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates
MG Purisai et al.
NEUROBIOLOGY OF DISEASE (2005)
Multiple regions of α-synuclein are associated with Parkinson's disease
JC Mueller et al.
ANNALS OF NEUROLOGY (2005)
Helix periodicity, topology, and dynamics of membrane-associated α-Synuclein
R Bussell et al.
PROTEIN SCIENCE (2005)
Release of long-range tertiary interactions potentiates aggregation of natively unstructured α-synuclein
CW Bertoncini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
AM Cuervo et al.
SCIENCE (2004)
A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed α-synuclein
C Zhou et al.
MOLECULAR THERAPY (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Yeast genes that enhance the toxicity of a mutant huntingtin fragment or α-synuclein
S Willingham et al.
SCIENCE (2003)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
α-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma
OMA El-Agnaf et al.
FASEB JOURNAL (2003)
Endoproteolytic activity of the proteasome
CW Liu et al.
SCIENCE (2003)
Evidence that α-synuclein functions as a negative regulator of Ca+ +-dependent α-granule release from human platelets
SM Park et al.
BLOOD (2002)
Dependence of α-synuclein aggregate morphology on solution conditions
W Hoyer et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red
M Sakamoto et al.
EXPERIMENTAL NEUROLOGY (2002)
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
JE Duda et al.
ANNALS OF NEUROLOGY (2002)
α-Synuclein is phosphorylated in synucleinopathy lesions
H Fujiwara et al.
NATURE CELL BIOLOGY (2002)
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
BCV Campbell et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Effect of allelic variation at the NACP-Rep1 repeat upstream of the α-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system
O Chiba-Falek et al.
HUMAN MOLECULAR GENETICS (2001)
Human and mouse alpha-synuclein genes: Comparative genomic sequence analysis and identification of a novel gene regulatory element
JW Touchman et al.
GENOME RESEARCH (2001)
α-Synuclein immunoreactivity in dementia with Lewy bodies:: morphological staging and comparison with ubiquitin immunostaining
E Gómez-Tortosa et al.
ACTA NEUROPATHOLOGICA (2000)
Expression patterns of α-synuclein in human hematopoietic cells and in Drosophila at different developmental stages
EC Shin et al.
MOLECULES AND CELLS (2000)
Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha-synuclein in human and transgenic mouse brain
PJ Kahle et al.
JOURNAL OF NEUROSCIENCE (2000)
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