Journal
NPJ PARKINSONS DISEASE
Volume 7, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41531-021-00203-9
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Categories
Funding
- Charitable Hertie Foundation
- German Center for Neurodegenerative diseases
- German Research Foundation (DFG)
- German Ministry for Science
- European Commission
- Michael J. Fox Foundation for Parkinson's Research (MJFF)
- European Union's Horizon 2020 research and innovation program
- EFPIA Innovative Medicines Initiative 2
- EPFL
- MJFF
- NIH [R01 NS09435, DA07418]
- ASAP Foundation
- JPB Foundation
- National Health and Medical Research Council of Australia
- Uttra & Subash Bhargava Family
- Parkinson's Research Consortium Ottawa
- Program in Neuroscience at The Ottawa Hospital
- Lundbeck Foundation [R223-2015-4222, R248-2016-2518]
- Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Denmark
- Parkinsonsforeningen
- Parkinson's Foundation
- Deutsche Forschungsgemeinschaft (DFG)
- EU (Horizon2020)
- Parkinson Fonds Deutschland
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy [EXC 2067/1- 390729940, SFB1286]
- MJFF Foundation
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The authors aim to summarize critical features of alpha-synuclein and identify knowledge gaps in PD research to propose future research directions. Their goal is to develop therapies that can slow or stop the progression of PD.
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, alpha-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US alone. Since the initial association with PD, hundreds of researchers have contributed to elucidating the functions of alpha-synuclein in normal and pathological states, and these remain critical areas for continued research. With this position paper the authors strive to achieve two goals: first, to succinctly summarize the critical features that define alpha-synuclein's varied roles, as they are known today; and second, to identify the most pressing knowledge gaps and delineate a multipronged strategy for future research with the goal of enabling therapies to stop or slow disease progression in PD.
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