Journal
NPJ PRECISION ONCOLOGY
Volume 5, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41698-021-00200-4
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Funding
- 'Tou Yan' Action of Heilongjiang province
- National Natural Science Foundation of China [81871976, 81872435, 81672930]
- Excellent Youth Foundation of Heilongjiang Province [JQ2019H003]
- Key Program of the HAIYAN Foundation [JJZD2018-05]
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This study reveals the complex interplay between EMT and immune evasion, as well as their significant impact on tumor behavior and clinical outcomes. Quantitative analysis identified factors associated with the balance between EMT and immune evasion, such as cellular composition, mutation burden, chromosomal stability, and oncogenic gene alterations. The proposed EMT-CYT Index (ECI) scoring model emerged as a superior predictor of prognosis and immunotherapy response across different malignancies.
An emerging body of evidence has recently recognized the coexistence of epithelial-mesenchymal transition (EMT) and immune response. However, a systems-level view and survey of the interplay between EMT and immune escape program, and their impact on tumor behavior and clinical outcome across various types of cancer is lacking. Here, we performed comprehensive multi-omics analyses to characterize the landscape of crosstalk between EMT and immune evasion and their clinical relevance across 17 types of solid cancer. Our study showed the presence of complex and dynamic immunomodulatory crosstalk between EMT and immune evasion shared by pan-cancer, and the crosstalk was significantly associated with cancer prognosis and immunotherapy response. Integrative quantitative analyses of genomics and immunogenomics revealed that cellular composition of immune infiltrates, non-synonymous mutation burden, chromosomal instability and oncogenic gene alterations are associated with the balance between EMT and immune evasion. Finally, we proposed a scoring model termed EMT-CYT Index (ECI) to quantify the EMT-immunity axis, which was a superior predictor of prognosis and immunotherapy response across different malignancies. By providing a systematic overview of crosstalk between EMT and immune evasion, our study highlights the potential of pan-cancer EMT-immunity crosstalk as a paradigm for dissecting molecular mechanisms underlying cancer progression and guiding more effective and generalized immunotherapy strategies.
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