Journal
BIOACTIVE MATERIALS
Volume 6, Issue 8, Pages 2523-2534Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.01.029
Keywords
Bioactive biomaterials; Multifunctional hydrogel; Extracellular vesicles release; Spinal cord injury repair
Funding
- National Natural Science Foundation of China [51872224, 81772379, 81972096, 81902238]
- Zhejiang Province Health Foundation, China [2018KY092, WKJ-ZJ-1903]
- Nature Science Foundation of Zhejiang Province, China [LQ18H060003]
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The study demonstrates that using a sustainable release hydrogel for extracellular vesicles can potentially improve motor functional recovery after spinal cord injury. This hydrogel not only encapsulates extracellular vesicles but also synergistically regulates therapeutic effects by suppressing inflammation and promoting neural regeneration.
The repair and motor functional recovery after spinal cord injury (SCI) remains a worldwide challenge. The inflammatory microenvironment is one of main obstacles on inhibiting the recovery of SCI. Using mesenchymal stem cells (MSCs) derived extracellular vesicles to replace MSCs transplantation and mimic cell paracrine secretions provides a potential strategy for microenvironment regulation. However, the effective preservation and controlled release of extracellular vesicles in the injured spinal cord tissue are still not satisfied. Herein, we fabricated an injectable adhesive anti-inflammatory F127-polycitrate-polyethyleneimine hydrogel (FE) with sustainable and long term extracellular vesicle release (FE@EVs) for improving motor functional recovery after SCI. The orthotopic injection of FE@EVs hydrogel could encapsulate extracellular vesicles on the injured spinal cord, thereby synergistically induce efficient integrated regulation through suppressing fibrotic scar formation, reducing inflammatory reaction, promoting remyelination and axonal regeneration. This study showed that combining extracellular vesicles into bioactive multifunctional hydrogel should have great potential in achieving satisfactory locomotor recovery of central nervous system diseases.
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