Journal
BIOACTIVE MATERIALS
Volume 6, Issue 6, Pages 1750-1764Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.11.024
Keywords
Legumain; Brain barrier; Efflux transport; Multi-drug delivery; Alzheimer's disease
Funding
- National Natural Science Foundation of China [51773152]
- Science and Technology Plans of Tianjin [15JCYBJC17900]
- Natural Science Foundation of Tianjin [18JCYBJC17500]
Ask authors/readers for more resources
The study successfully constructs stimuli-responsive self-assembled nanovesicles for delivering water-soluble drugs to prevent efflux transport of brain barriers in Alzheimer's disease brain microenvironment. The smart multi-drug delivery vesicle shows promising potential for AD treatment and other central nervous system disorders.
Brain barrier is both a protective permeability hurdle and a limitation site where therapeutic agents are excluded to enter the target region. Designing drug vehicle to overcome this notorious barrier bottle is challenging. Herein, we construct a stimuli-responsive self-assembled nanovesicle that delivers water-soluble drugs to prevent the efflux transport of brain barriers by responding to the endogenously occurring signals in Alzheimer's disease (AD) brain microenvironment. Once stimuli-responsive vesicles are accumulated in intracerebrally, the intrinsically occurring legumain endopeptidase cleaves the Ac-Ala-Ala-Asn-Cys-Asp (AK) short peptide on the drug vesicles to expose the 1,2 thiol amino group to cyclize with the cyano groups on 2-cyano-6-aminobenzothiazole (CABT) of the chaperone vesicles, thus triggering the formation of cross-linked micrometre-scale vesicles. Such a structural alteration completely prevents further brain barriers efflux. The superior neuroprotective capacity of cross-linked vesicles is validated in senescence accelerated mouse prone 8 (SAMP8). This smart multi-drug delivery vesicle is promising to serve as a powerful system for AD treatment and can be adapted for the therapy of other central nervous system (CNS) disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available