Journal
BIOACTIVE MATERIALS
Volume 6, Issue 7, Pages 1878-1909Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.12.001
Keywords
Poly(alpha-L-lysine); Antimicrobial agents; Delivery systems; Bio-sensing; Bio-imaging
Funding
- National Natural Science Foundation of China, China [81803467]
- 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant, Hong Kong [2020LKSFG18B, 2020LKSFG02E]
- grant for Key Disciplinary Project of Clinical Medicine under the Guangdong High-Level University Development Program, Guangdong, China [002-18120314, 002-18120311]
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Poly(alpha-L-lysine) (PLL) is a water-soluble, cationic biopolymer composed of alpha-L-lysine structural units. Over the past decade, significant progress has been made in the synthesis and biomedical applications of PLL, including antibacterial agents, gene/drug/protein delivery systems, bio-sensing, bio-imaging, and tissue engineering. Despite the promising potential of PLL-based nanomaterials in biomedical fields, challenges and perspectives still need to be addressed.
Poly(alpha-L-lysine) (PLL) is a class of water-soluble, cationic biopolymer composed of alpha-L-lysine structural units. The previous decade witnessed tremendous progress in the synthesis and biomedical applications of PLL and its composites. PLL-based polymers and copolymers, till date, have been extensively explored in the contexts such as antibacterial agents, gene/drug/protein delivery systems, bio-sensing, bio-imaging, and tissue engineering. This review aims to summarize the recent advances in PLL-based nanomaterials in these biomedical fields over the last decade. The review first describes the synthesis of PLL and its derivatives, followed by the main text of their recent biomedical applications and translational studies. Finally, the challenges and perspectives of PLL-based nanomaterials in biomedical fields are addressed.
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