Journal
SMALL METHODS
Volume 5, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smtd.202100536
Keywords
3D-printed scaffolds; bone regeneration; bone-metastatic breast cancer; chemodynamic therapy; photothermal therapy
Funding
- National Natural Science Foundation of China [81701817, 81800941, 81772428]
- Natural Science Foundation of Guangdong Province [2019A1515011498, 2018A0303130347, 2018A0303130019]
- Dongguan University of Technology [KCYCXPT201603, TDYB2019003]
- Department of Education of Guangdong Province, China [2016KQNCX168, 2017KZDXM082]
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A bifunctional scaffold 3D-printed from nanoink containing metallic polydopamine nanoparticles (FeMg-NPs) is developed to eliminate tumor cells and repair bone defects associated with bone metastasis in breast cancer patients. This approach combines chemodynamic therapy with photothermal therapy to efficiently eradicate bone-metastatic tumors while promoting new bone formation.
Bone metastasis occurs in about 70% of breast cancer patients. The surgical resection of metastatic tumors often leads to bone erosion and destruction, which greatly hinders the treatment and prognosis of breast cancer patients with bone metastasis. Herein, a bifunctional scaffold 3D-printed from nanoink is fabricated to simultaneously eliminate the tumor cells and repair the tumor-associated bone defects. The metallic polydopamine (PDA) nanoparticles (FeMg-NPs) may effectively load and sustainably release the metal ions Fe3+ and Mg2+ in situ. Fe3+ exerts a chemodynamic therapy to synergize with the photothermal therapy induced by PDA with effective photothermal conversion under NIR laser, which efficiently eliminates the bone-metastatic tumor. Meanwhile, the sustained release of osteoinductive Mg2+ from the bony porous 3D scaffold enhances the new bone formation in the bone defects. Taken together, the implantation of scaffold (FeMg-SC) 3D-printed from the FeMg-NPs-containing nanoink provides a novel strategy to simultaneously eradicate bone-metastatic tumor and repair the tumor-associated bone defects.
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