Landscape of Cell Communication in Human Dental Pulp

The cellular atlas of the stroma is not well understood. Here, the cell populations in human dental pulp through single-cell RNA sequencing are profiled. Dental pulp stem cells, pulp cells, T cells, macrophages, endothelial cells, and glial cells are identified in human dental pulp. These cells support each other through sending growth signals. Based on the appearance of ligand-receptor pairs between two cell populations, pulp cells have the greatest communication with other cell types, while T cells have the least communication. In addition, T cells expressing TLR1, TLR2, and TLR4, and endothelial cells expressing TLR4, monitor bacterial invasion. These findings provide the census of normal dental pulp.

Automated summary

The study revealed various cell populations in human dental pulp, including dental pulp stem cells, T cells, macrophages, etc., which support each other through growth signals. Pulp cells have the greatest communication with other cell types, while T cells have the least. T cells and endothelial cells play a role in monitoring bacterial invasion through specific receptor expressions. These findings provide insights into the cellular composition of normal dental pulp.