Sprayable antibacterial Persian gum-silver nanoparticle dressing for wound healing acceleration

Wound infection is considered a significant challenge in skin injuries. Sprayable antibacterial wound dressings are interesting alternatives to their traditional counterparts because of their facile preparation, ease-of-use, and the possibility of topical delivery of antibacterial materials. Herein, novel sprayable antibacterial dressings are formulated and reported. The dressings were developed by in-situ formation of Ag-nanoparticles (Ag-NPs) using Persian gum (PG) as a carbohydrate polymer. Several tests were conducted to investigate the effect of polymer concentration on the sprayablity, biocompatibility, and antibacterial activity of the dressings (PG/Ag-NPs). Results showed that formulations up to 2 wt.% PG/Ag-NPs could be sprayed properly and form intact films. Antibacterial evaluations also showed biocidal activity of 1% PG/Ag-NPs against Pseudomonas aeruginosa and Staphylococcus aureus. Cytotoxicity and in vivo full-thickness wound healing evaluation confirmed that 1% PG/ Ag-NPs spray was safe and improved wound healing process. All the results confirmed the high potential of formulated sprayable dressings for wound repair.

Automated summary

Novel sprayable antibacterial dressings were developed by in-situ formation of Ag-nanoparticles using Persian gum as a carbohydrate polymer. The dressings showed good sprayability, antibacterial activity, and biocompatibility, indicating high potential for wound repair.