Journal
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
Volume 44, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colcom.2021.100493
Keywords
Methylcellulose; Bile salt; Pyrene; Fluorescence; Aggregation; Thermodynamic parameters
Funding
- DST-Sci-ence and Engineering Research Board (SERB) [ECR/2016/000692]
- Government of India
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The interaction between cellulose ether and bile salt was investigated using various methods, revealing its potential impact on lipid digestion. By calculating different parameters, the micellization properties of the MC/NaDC mixed system were explored. This study provides a comprehensive understanding of the mixed system's implications on lipid digestion.
The cellulose ether and bile salt mixed systems have a potential to alter the lipid digestion. The basic understanding of the aggregation process, interaction, and physicochemical properties of cellulose ether and bile salt is an essential topic of study. In this work, the interaction between simple dietary fiber methylcellulose (MC) and bile salt sodium deoxycholate (NaDC) has been studied using UV-Vis absorption, steady-state fluorescence intensity, fluorescence quenching, conductivity, light scattering, and zeta potential measurements. Fluorescence properties of hydrophobic probe pyrene were used to find the critical aggregation concentration (CAC), critical micellar concentration (CMC), and aggregation number (N-agg) of the MC/NaDC system. Using conventional conductivity method CAC, CMC, and thermodynamic parameters of micellization i.e. standard Gibbs free energy (Delta(0)(Gmic)), standard entropy (Delta S-mic(0)), and standard enthalpy (Delta(0)(Hmic)), was calculated to know the information regarding the nature of micellization of MC/NaDC mixed system. The size distribution and zeta potential study give an insight into MC/NaDC interaction before and after the CAC point. The strong hydrophobic interaction between cellulose ether MC and bile salt NaDC shows that this mixed system may have further implications in lipid digestion.
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