4.6 Article

Fluids Alter Elasticity Measurements: Porous Wave Propagation Accounts for Shear Wave Dispersion in Elastography

Journal

FRONTIERS IN PHYSICS
Volume 9, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fphy.2021.697990

Keywords

liver characterization; shear wave elastography; poroelasticity; ultrasound imaging; viscoelasticity; biot theory; shear wave dispersion; voigt model

Funding

  1. Plan Cancer ARC-2018-PhysiCancer-BPALP

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Shear wave elastography converts rotational wave speeds to elasticity measures using elastodynamic theory, serving as the gold standard for non-invasive liver fibrosis detection. However, the observed shear wave dispersion in vivo human liver mismatches with elastic and visco-elastic wave propagation theory. Considering porosity and fluid viscosity in converting shear wave speeds to elasticity in soft porous materials is essential. Comparing Biot's theory with Voigt's model suggests that accounting for dispersion due to fluid viscosity could enhance shear wave imaging in the liver and other highly vascularized organs.
In shear wave elastography, rotational wave speeds are converted to elasticity measures using elastodynamic theory. The method has a wide range of applications and is the gold standard for non-invasive liver fibrosis detection. However, the observed shear wave dispersion of in vivo human liver shows a mismatch with purely elastic and visco-elastic wave propagation theory. In a laboratory phantom experiment we demonstrate that porosity and fluid viscosity need to be considered to properly convert shear wave speeds to elasticity in soft porous materials. We extend this conclusion to the clinical application of liver stiffness characterization by revisiting in vivo studies of liver elastography. To that end we compare Biot's theory of poro-visco-elastic wave propagation to Voigt's visco-elastic model. Our results suggest that accounting for dispersion due to fluid viscosity could improve shear wave imaging in the liver and other highly vascularized organs.

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