Journal
FRONTIERS IN VETERINARY SCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2021.639719
Keywords
hyperprolific sows; prenatal exposure; neonatal programming; phytogenic compounds; piglet gut health
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Funding
- DELACON Biotechnik GmbH (Engerwitzdorf, Austria)
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The study found that supplementing gestating hyperprolific sow diets with a specific blend of phytogenic compounds (BPC) can influence neonatal gut morphology and gene expression related to intestinal health. This led to increased villus height and goblet cell volume density in the jejunum, as well as changes in gene expression associated with nutrient transport and immune response.
This research aims to determine whether a specific blend of phytogenic compounds (BPC) supplemented in gestating hyperprolific sow diets can promote prenatal maternal effects in terms of piglet gut function and morphology. Twenty-eight (Landrace x Yorkshire) gilts and sows (parity 0 to 7) were randomly distributed by parity number and body weight into two dietary treatments: unsupplemented Control (CON) (n = 14) or CON diet supplemented with 1 g/kg feed of BPC during gestation (n = 14). The BPC supplementation during gestation of sows downregulated the neonate piglets' jejunal genes involved in oxidation (SOD2) and nutrient transport (SLC16A1/MCT1, SLC11A2/DMT1, and SLC39A/ZIP4), while IFNG and CLDN4 related to immune response and barrier function, respectively, were upregulated (q < 0.10). In addition, the jejunal villus height and the ratio of the villus height to crypt depth tended to increase (p < 0.10), while goblet cell volume density was higher (p < 0.05) in BPC compared to CON. In conclusion, dietary supplementation of BPC in gestating diets for hyperprolific sows influences neonatal histomorphology and expression of genes related to the intestinal function and health.
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