Journal
FRONTIERS IN VETERINARY SCIENCE
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2021.693641
Keywords
eccDNA; microDNA; tumor; livestock; molecular marker
Categories
Funding
- Key Research and Development Plan (modern agriculture) in Jiangsu Province [BE2018354]
- Jiangsu Agricultural Science and Technology Innovation Fund [XC(18)2003]
- major projects of Natural Science Research of colleges and universities in Jiangsu Province [17KJA230001]
- National Natural Science Foundation of China [31872333]
- major new varieties of agricultural projects in Jiangsu Province [PZCZ201739]
- National Natural Science Foundation of Cooperation on International Agricultural Research Organization [3201101559]
- Open Project of Joint International Research Laboratory of Agriculture and Agri-Product Safety
- Ministry of Education of China [JILAR-KF202103]
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Extrachromosomal circular DNA (eccDNA), a type of double-stranded circular DNA derived from and separate from chromosomes, is common in eukaryotes with strong heterogeneity in count, length, and origin. It has been shown to play important roles in various biological processes in eukaryotic cells.
Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin. It has been demonstrated that eccDNA could function in telomere and rDNA maintenance, aging, drug resistance, tumorigenesis, and phenotypic variations of plants and animals. Here we review the current knowledge about eccDNA in category, biogenesis, recognition, and functions. We also provide perspectives on the potential implications of eccDNA in life science.
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