Journal
DIAGNOSTICS
Volume 11, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/diagnostics11091720
Keywords
microRNAs; biomarkers; inherited cardiomyopathies; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; hypertrophic cardiomyopathy
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MiRNAs are small non-coding RNAs involved in regulating biochemical pathways in the human body; their levels can be altered due to pathophysiological mechanisms, making them potential biomarkers for cardiac diseases and other pathological conditions. This review summarizes findings of miRNA biomarkers in the three most common structural cardiomyopathies.
MicroRNAs (miRNAs) are a class of non-coding RNAs of about 20 nucleotides in length, involved in the regulation of many biochemical pathways in the human body. The level of miRNAs in tissues and circulation can be deregulated because of altered pathophysiological mechanisms; thus, they can be employed as biomarkers for different pathological conditions, such as cardiac diseases. This review summarizes published findings of these molecular biomarkers in the three most common structural cardiomyopathies: human dilated, arrhythmogenic and hypertrophic cardiomyopathy.
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