One-Pot Multicomponent Coupling Reaction of Catechols, Benzyl Alcohols/Benzyl Methyl Ethers, and Ammonium Acetate toward Synthesis of Benzoxazoles

The multicomponent coupling reaction of catechol, ammonium acetate, and benzyl alcohol/benzyl methyl ether in the presence of a Fe(III) catalyst precursor afforded benzoxazole derivatives in good to excellent yields. The notable features of this protocol are abundant availability of the catalyst system, large-scale synthesis, high diversity, and high yields of products.

Automated summary

The multicomponent coupling reaction using Fe(III) catalyst precursor to mix catechol, ammonium acetate, and benzyl alcohol/benzyl methyl ether produced benzoxazole derivatives with good to excellent yields. The protocol stands out for the availability of the catalyst system, potential for large-scale synthesis, high diversity of products, and high yields.