4.6 Article

Interaction of Human C5a with the Major Peptide Fragments of C5aR1: Direct Evidence in Support of Two-Site Binding Paradigm

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Binding of raloxifene to human complement fragment 5a (hC5a): a perspective on cytokine storm and COVID19

Richa Mishra et al.

Summary: hC5a, as a pro-inflammatory glycoprotein, plays an important role in drug research. Recent studies have shown that hC5a can cooperatively accommodate drugs at multiple sites, suggesting exploration of polypharmacology for targeting inflammatory diseases related to the "cytokine storm".

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Article Biochemistry & Molecular Biology

Resveratrol binding to human complement fragment 5a (hC5a) may modulate the C5aR signaling axes

Richa Mishra et al.

Summary: Resveratrol, a promiscuous phytoalexin found in fruits and nuts, exhibits health benefits through antioxidant and anti-inflammatory activities. It directly binds to COX-1, COX-2 enzymes, and (h)C5a, modulating inflammatory pathways and showing anti-inflammatory effects.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Review Biochemistry & Molecular Biology

The roles and potential therapeutic implications of C5a in the pathogenesis of COVID-19-associated coagulopathy

Jing Li et al.

Summary: Emerging evidence suggests a strong association between multisystem organ failure in COVID-19 patients and various coagulopathies, presenting a clinical challenge for treatment. Understanding the mechanisms of complement cascade activation in the genesis of COVID-19-associated coagulopathy could lead to the development of novel anticoagulant drugs targeting C5a/C5aRs signaling.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

Review Pharmacology & Pharmacy

Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics

Peter Garred et al.

Summary: The complement system is the host's defense friend by protecting it from invading pathogens, promoting tissue repair, and maintaining homeostasis. Complement is a double-edged sword, since when dysregulated or overactivated it becomes the host's enemy, leading to tissue damage, organ failure, and, in worst case, death. A number of acute and chronic diseases are candidates for pharmacological treatment to avoid complement-dependent damage, ranging from the well established treatment for rare diseases to possible future treatment of large patient groups like the pandemic coronavirus disease 2019.

PHARMACOLOGICAL REVIEWS (2021)

Article Biology

The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19

Aurosikha Das et al.

Summary: The complement system plays a crucial role in COVID19, with studies suggesting that neutralizing C5a can help in effectively managing the disease.

COMPUTATIONAL BIOLOGY AND CHEMISTRY (2021)

Article Multidisciplinary Sciences

Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis

Julien Carvelli et al.

NATURE (2020)

Article Multidisciplinary Sciences

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

David Jonathan Wasilko et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

A rational search for discovering potential neutraligands of human complement fragment 5a (hC5a)

Richa Mishra et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2019)

Review Endocrinology & Metabolism

Current understanding of the structure and function of family B GPCRs to design novel drugs

Vlasios Karageorgos et al.

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (2018)

Article Biochemistry & Molecular Biology

Orthosteric and allosteric action of the C5a receptor antagonists

Heng Liu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Orthosteric and allosteric action of the C5a receptor antagonists

Heng Liu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Multidisciplinary Sciences

The Model Structures of the Complement Component 5a Receptor (C5aR) Bound to the Native and Engineered hC5a

Amita Rani Sahoo et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727

Nathan Robertson et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

Structure and Function of Peptide-Binding G Protein-Coupled Receptors

Fan Wu et al.

JOURNAL OF MOLECULAR BIOLOGY (2017)

Article Biochemistry & Molecular Biology

New concepts on the therapeutic control of complement anaphylatoxin receptors

Owen A. Hawksworth et al.

MOLECULAR IMMUNOLOGY (2017)

Article Biochemistry & Molecular Biology

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

Joshua J. Ziarek et al.

SCIENCE SIGNALING (2017)

Article Biochemistry & Molecular Biology

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

Joshua J. Ziarek et al.

SCIENCE SIGNALING (2017)

Article Biochemistry & Molecular Biology

Allosterism in human complement component 5a ((h)C5a): a damper of C5a receptor (C5aR) signaling

Soumendra Rana et al.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2016)

Article Chemistry, Medicinal

g_mmpbsa-A GROMACS Tool for High-Throughput MM-PBSA Calculations

Rashmi Kumari et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)

Review Cell Biology

Complement and its role in innate and adaptive immune responses

Jason R. Dunkelberger et al.

CELL RESEARCH (2010)

Article Biochemistry & Molecular Biology

The role of the anaphylatoxins in health and disease

Andreas Klos et al.

MOLECULAR IMMUNOLOGY (2009)

Article Chemistry, Physical

GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation

Berk Hess et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2008)

Review Pharmacology & Pharmacy

Function, structure and therapeutic potential of complement C5a receptors

P. N. Monk et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Article Biochemistry & Molecular Biology

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding

Anne-Marie Scola et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking

Ian S. Hagemann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Computational design of proteins stereochemically optimized in size, stability, and folding speed

Sadhna Joshi et al.

BIOPOLYMERS (2006)

Article Biochemistry & Molecular Biology

Essential role for the second extracellular loop in C5a receptor activation

JM Klco et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)