Journal
PLANTS-BASEL
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/plants10071400
Keywords
Croton zehntneri; essential oil; proximal tubule; tubulointerstitial injury; proteinuria; kidney
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [423724/2018-5, 309795/2018-4, 303793/2015-5, 401700/2020-8]
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro [E-26/202.556/2019, E-26/210.930/2019, E-26/211.710/2015, E-26/202.833/2017, E-26/010.000983/2019, E-26/210.181/2020]
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The study found that high doses of Croton zehntneri essential oil may induce tubule-interstitial injury in mouse kidneys, possibly mediated by protein overload in the proximal tubule.
The essential oil of Croton zehntneri (EOCZ) and its major compounds are known to have several biological activities. However, some evidence shows potential toxic effects of high doses of EOCZ (>300 mg/kg) in amphibian and human kidneys. The aim of the present work was to investigate the effects on renal function of EOCZ at 300 mg/kg/day in healthy Swiss mice and a subclinical acute kidney injury (subAKI) animal model, which presents tubule-interstitial injury (TII). Four experimental groups were generated: (1) CONT group (control); (2) EOCZ, mice treated with EOCZ; (3) subAKI; (4) subAKI+EOCZ, subAKI treated simultaneously with EOCZ. EOCZ treatment induced TII measured by increases in (1) proteinuria; (2) cortical tubule-interstitial space; (3) macrophage infiltration; (4) collagen deposition. A decrease in tubular sodium reabsorption was also observed. These results were similar and nonadditive to those observed in the subAKI group. These data suggest that treatment with EOCZ at higher concentrations induces TII in mice, which could be mediated by protein overload in the proximal tubule.
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