Journal
BRAIN SCIENCES
Volume 11, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/brainsci11060718
Keywords
Alzheimer's disease; semantic-lexical processing; fMRI analysis; naming task
Categories
Funding
- Ministry of Science and Technology Taiwan
- MOST [108-2634-F-367-001, MOST 109-2634-F-367-001, MOST 110-2634-F-367-001]
- Allied Advanced Intelligent Biomedical Research Center (A2IBRC) under the Higher Education Sprout Project of Ministry of Education [13001090182-EDU]
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In this study, fMRI was used to observe neural activity in HC and AD groups, revealing decreased neural activity in the AD group during a semantic task, leading to semantic deficit problems. Additionally, ROI analysis showed both hyperactivation and hypoactivation in the AD group, indicating the compensatory mechanism observed in AD character profile.
For decades, scientists have been trying to solve the problem of dementia, with no cure currently available. Semantic-lexical impairment is well established as the early critical sign of dementia, although there are still gaps in knowledge that must be investigated. In this study, we used fMRI to observe the neural activity of 31 subjects, including 16 HC (Healthy Control) and 15 AD (Alzheimer's Disease), who participated in the naming task. The neuropsychology profile of HC (Healthy Control) and AD (Alzheimer's Disease) are discussed in this study. The involvement of FG (Fusiform Gyrus) and IFG (Inferior Frontal Gyrus) shows dominant activation in both of the groups. We observed a decrease in neural activity in the AD group, resulting in semantic deficit problems in this preliminary study. Furthermore, ROI analysis was performed and revealed both hyperactivation and hypoactivation in the AD group. The compensatory mechanism demonstrated during the task, due to the effort required to identify an animal's name, represents the character profile of AD.
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