Journal
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnint.2021.682019
Keywords
modified miniscope system; probe; high resolution; electrophysiology recording; calcium imaging
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Funding
- National Key Technologies RD Program [2017YFA0205903, 2017YFA0701100, 2016YFB0402405]
- National Natural Science Foundation of China [61634006, 61671424]
- Strategic Priority Research Program of CAS Pilot Project [XDB32030100, XDB32040200]
- Key Research Program of Frontier Science, CAS [QYZDY-SSW-JSC004]
- Beijing ST Planning Task [Z161100002616019]
- CAS Pilot Project [XDA16020902]
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The study successfully achieved simultaneous recording of Ca2+ signals and local field potential (LFP) signals in the hippocampus CA1 region of adult mice using the modified miniscope system.
The miniscope system is one of the calcium (Ca2+) imaging tools with small size and lightweight and can realize the deep-brain Ca2+ imaging not confined to the cerebral cortex. Combining Ca2+ imaging and electrophysiology recording has been an efficient method for extracting high temporal-spatial resolution signals in the brain. In this study, a particular electrode probe was developed and assembled on the imaging lens to modify the miniscope system. The electrode probe can be tightly integrated into the lens of the miniscope without increasing the volume, weight, and implantation complexity. In vivo tests verified that the proposed modified system has realized the simultaneous recording of Ca2+ signals and local field potential (LFP) signal in the hippocampus CA1 region of an adult mouse.
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