Journal
ANTIBIOTICS-BASEL
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/antibiotics10060627
Keywords
antibiotic resistance; antiphage antibody; immune system; phage therapy; urogenital tract infections
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Funding
- statutory funds of the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
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Phage therapy for urogenital infections showed promising results, with low antibody responses in patients.
Patients with chronic urinary and urogenital multidrug resistant bacterial infections received phage therapy (PT) using intravesical or intravesical and intravaginal phage administration. A single course of PT did not induce significant serum antibody responses against administered phage. Whilst the second cycle of PT caused a significant increase in antibody levels, they nevertheless remained quite low. These data combined with good therapy results achieved in some patients suggest that this mode of PT may be an efficient means of therapy for urogenital infections and a reliable model for a clinical trial of PT.
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