Journal
FOODS
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/foods10071478
Keywords
marine polyphenols; phlorotannins; brown seaweeds; antioxidant; anti-inflammatory; anti-tumor; oxidative stress; inflammation; cancer
Categories
Funding
- FCT/MCTES (FCT/MEC, Fundacao para a Ciencia e Tecnologia e Ministerio da Educacao e Ciencia) [UIDB/50006/2020, UIDP/50006/2020]
- FCT (Fundacao para a Ciencia e Tecnologia) [PD/BD/114577/2016]
- ESF (European Social Fund) through POCH (Programa Operacional Capital Humano) [PD/BD/114577/2016]
- [PTDC/BAA-AGR/31015/2017]
- Fundação para a Ciência e a Tecnologia [PTDC/BAA-AGR/31015/2017, PD/BD/114577/2016] Funding Source: FCT
Ask authors/readers for more resources
According to the WHO, cancer was the second global leading cause of death in 2018, with poor behavioral and dietary habits being the main risk factors. Polyphenols, particularly phlorotannins, have shown exceptional bioactive properties and potential for application in cancer prevention and treatment by interfering with biochemical mechanisms related to oxidative stress, inflammation and tumorigenesis. The versatility and ability of phlorotannins to act at different stages and mechanisms of cancer growth make them highly appealing for developing new therapeutic strategies to combat this worldwide scourge.
According to the WHO, cancer was responsible for an estimated 9.6 million deaths in 2018, making it the second global leading cause of death. The main risk factors that lead to the development of this disease include poor behavioral and dietary habits, such as tobacco use, alcohol use and lack of fruit and vegetable intake, or physical inactivity. In turn, it is well known that polyphenols are deeply implicated with the lower rates of cancer in populations that consume high levels of plant derived foods. In this field, phlorotannins have been under the spotlight in recent years since they have shown exceptional bioactive properties, with great interest for application in food and pharmaceutical industries. Among their multiple bioactive properties, phlorotannins have revealed the capacity to interfere with several biochemical mechanisms that regulate oxidative stress, inflammation and tumorigenesis, which are central aspects in the pathogenesis of cancer. This versatility and ability to act either directly or indirectly at different stages and mechanisms of cancer growth make these compounds highly appealing for the development of new therapeutical strategies to address this world scourge. The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress-inflammation network, emphasizing their potential for application in cancer prevention and/or treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available