Journal
NATURE AND SCIENCE OF SLEEP
Volume 13, Issue -, Pages 775-789Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NSS.S297702
Keywords
sleep; inflammation; allergy; rheumatoid arthritis
Categories
Funding
- Hedlund Foundation
- Karolinska Institute
- Hjart-Lungfonden
- Swedish Asthma and Allergy Association
- Swedish Research Council
- Center for Allergy Research
- Stockholm Stress Center
- Isabella and Henrik Berg and Heumanska stiftelsen/Hjarnfonden
- Per and Ingrid Nydahl
- Osher Center for Integrative Medicine
- Swedish Council for Working Life and Social Research
- European Union [602919]
- Swedish Foundation for Strategic Research
- Stockholm County Council
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The study tentatively indicates that both patients with allergy and RA display sleep alterations, but inflammation is not an independent predictor of sleep disturbance across these patient groups.
Introduction: Disturbed sleep in inflammatory disorders such as allergy and rheumatoid arthritis (RA) is common and may be directly or indirectly related to disease processes, but has not been well characterized in these patient groups, especially not with objective methods. Aim: The present study aimed to characterize objective and subjective sleep in patients with allergy or RA using sleep diaries, one-channel EEG and actigraphy. It also aimed to investigate if sleep measures were associated with central immune activation, assessed using translocator protein (TSPO) positron emission tomography, as well as cytokine markers of peripheral inflammation and disease-specific symptoms or general symptoms of sickness. Methods: In total, 18 patients with seasonal pollen allergy, 18 patients with RA and 26 healthy controls were included in the study. Allergy patients and matched controls were assessed twice, in and out of pollen season, and RA patients and controls were assessed once. Sleep was recorded for approximately 1 week at each occasion. Results: Patients with allergy had increased levels of slow-wave sleep during pollen season. In contrast, patients with RA had less SWS compared to healthy controls, while no differences were observed in sleep duration or subjective sleep quality. Across groups, neither proinflammatory cytokines, grey matter TSPO levels nor general sickness symptoms were associated with objective or subjective measures of sleep. Rhinitis, but not conjunctivitis, was correlated to worse subjective sleep and more slow wave sleep in allergy. Functional status, but not disease activity, predicted lower subjective sleep in RA. Conclusion: This study tentatively indicates that both patients with allergy and RA display sleep alterations but does not support inflammation as an independent predictor of the sleep disturbance across these patient groups.
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