4.6 Review

Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases

Journal

METABOLITES
Volume 11, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/metabo11070418

Keywords

metabolomics; metabolites; biomarkers; analytical tools; diseases; diabetes; obesity

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Metabolomics is a branch of omics sciences that aims to identify and assess small molecules in samples for their diagnostic and therapeutic potentials. It has been utilized in various aspects of life and has shown potential in biomarker discovery for disease diagnosis and management. However, challenges remain in translating laboratory discoveries to clinical applications.
Metabolomics is a branch of 'omics' sciences that utilises a couple of analytical tools for the identification of small molecules (metabolites) in a given sample. The overarching goal of metabolomics is to assess these metabolites quantitatively and qualitatively for their diagnostic, therapeutic, and prognostic potentials. Its use in various aspects of life has been documented. We have also published, howbeit in animal models, a few papers where metabolomic approaches were used in the study of metabolic disorders, such as metabolic syndrome, diabetes, and obesity. As the goal of every research is to benefit humankind, the purpose of this review is to provide insights into the applicability of metabolomics in medicine vis-a-vis its role in biomarker discovery for disease diagnosis and management. Here, important biomarkers with proven diagnostic and therapeutic relevance in the management of disease conditions, such as Alzheimer's disease, dementia, Parkinson's disease, inborn errors of metabolism (IEM), diabetic retinopathy, and cardiovascular disease, are noted. The paper also discusses a few reasons why most metabolomics-based laboratory discoveries are not readily translated to the clinic and how these could be addressed going forward.

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