Journal
REGENERATIVE BIOMATERIALS
Volume 8, Issue 5, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbab037
Keywords
burn injury; wound dressing; silver nanoparticle; antimicrobial activity
Categories
Funding
- National Natural Science Foundation of China [31800796]
- Nature Sciences Funding of Fujian Province [2019J01238]
- Fuzhou University Testing Fund of Precious Apparatus [2021T018]
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A sandwich structure composite wound dressing with long-term antimicrobial activity and wound healing promotion was developed and demonstrated superior wound healing effect on deep dermal burns in a porcine model. It has great potential application in severe wound care.
Wounds may remain open for a few weeks in severe burns, which provide an entry point for pathogens and microorganisms invading. Thus, wound dressings with long-term antimicrobial activity are crucial for severe burn wound healing. Here, a sandwich structure composite wound dressing anchored with silver nanoparticles (AgNPs) was developed for severe burn wound healing. AgNPs were in situ synthesized on the fibers of chitosan nonwoven fabric (CSNWF) as the interlayer of wound dressing for sustained release of silver ion. The firmly anchored AgNPs could prevent its entry into the body, thereby eliminating the toxicity of nanomaterials. The outer layer was a polyurethane membrane, which has a nanoporous structure that could maintain free transmission of water vapor. Chitosan/collagen sponge was selected as the inner layer because of its excellent biocompatibility and biodegradability. The presence of AgNPs in the CSNWF was fully characterized, and the high antibacterial activity of CSNWF/AgNPs was confirmed by against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The superior wound healing effect on deep dermal burns of presented composite wound dressing was demonstrated in a porcine model. Our finding suggested that the prepared AgNPs doped sandwich structure composite wound dressing has great potential application in severe wound care.
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