Journal
PATHOGENS
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/pathogens10070913
Keywords
organoid; induced pluripotent stem cell; Parkinson's disease; neurotransmission; neuroimmunity; neuroinflammation; Chikungunya; neuroinvasive
Categories
Ask authors/readers for more resources
This study revealed that after Chikungunya virus infection, cerebral organoids from Parkinson's patients exhibited a different response compared to those from non-Parkinson's patients. Neurotransmission data showed dysregulation of IL-1, IL-10, and IL-6, potentially contributing to persistent depression in patients post-infection. Both types of organoids showed increased expression of CXCL10, which is linked to demyelination.
(1) Background: Arboviruses of medical and veterinary significance have been identified on all seven continents, with every human and animal population at risk for exposure. Like arboviruses, chronic neurodegenerative diseases, like Alzheimer's and Parkinson's disease, are found wherever there are humans. Significant differences in baseline gene and protein expression have been determined between human-induced pluripotent stem cell lines derived from non-Parkinson's disease individuals and from individuals with Parkinson's disease. It was hypothesized that these inherent differences could impact cerebral organoid responses to viral infection. (2) Methods: In this study, cerebral organoids from a non-Parkinson's and Parkinson's patient were infected with Chikungunya virus and observed for two weeks. (3) Results: Parkinson's organoids lost mass and exhibited a differential antiviral response different from non-Parkinson's organoids. Neurotransmission data from both infected non-Parkinson's and Parkinson's organoids had dysregulation of IL-1, IL-10, and IL-6. These cytokines are associated with mood and could be contributing to persistent depression seen in patients following CHIKV infection. Both organoid types had increased expression of CXCL10, which is linked to demyelination. (4) Conclusions: The differential antiviral response of Parkinson's organoids compared with non-Parkinson's organoids highlights the need for more research in neurotropic infections in a neurologically compromised host.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available