Journal
PATHOGENS
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/pathogens10080973
Keywords
alphavirus; antibody; assembly; eastern equine encephalitis virus; structure
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Funding
- University of Maryland School of Medicine (UOMSOM)
- University of Maryland Greenebaum Comprehensive Cancer Center
- UOMSOM Department of Biochemistry and Molecular Biology
- UOMSOM Center for Biomolecular Therapeutics
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Alphaviruses, including EEEV, cause encephalitis and arthritis in humans. Recent advances in the structural biology of EEEV, mainly based on cryoEM structures, provide insights into the interactions with host proteins, which may lead to therapeutic developments.
Alphaviruses are arboviruses that cause arthritis and encephalitis in humans. Eastern Equine Encephalitis Virus (EEEV) is a mosquito-transmitted alphavirus that is implicated in severe encephalitis in humans with high mortality. However, limited insights are available into the fundamental biology of EEEV and residue-level details of its interactions with host proteins. In recent years, outbreaks of EEEV have been reported mainly in the United States, raising concerns about public safety. This review article summarizes recent advances in the structural biology of EEEV based mainly on single-particle cryogenic electron microscopy (cryoEM) structures. Together with functional analyses of EEEV and related alphaviruses, these structural investigations provide clues to how EEEV interacts with host proteins, which may open avenues for the development of therapeutics.
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