Journal
PATHOGENS
Volume 10, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/pathogens10060729
Keywords
chagas disease; Trypanosoma cruzi; benznidazole; therapeutic strategies; mice
Categories
Funding
- Universidade Federal de Ouro Preto (UFOP)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- CNPq
- BERENICE (European Commission under the Health Innovation Work Programme of the 7th Framework Programme)
- CAPES-Science Without Borders
Ask authors/readers for more resources
The study found that different treatment regimens have varying efficacy on mice infected with different strains, leading to differences in treatment outcomes and side effects. Improving treatment adherence may help enhance the effectiveness of Chagas disease treatment.
As the development of new drugs for Chagas disease is not a priority due to its neglected disease status, an option for increasing treatment adherence is to explore alternative treatment regimens, which may decrease the incidence of side effects. Therefore, we evaluated the efficacy of different therapeutic schemes with benznidazole (BNZ) on the acute and chronic phases of the disease, using mice infected with strains that have different BNZ susceptibilities. Our results show that the groups of animals infected by VL-10 strain, when treated in the chronic phase with a lower dose of BNZ for a longer period of time (40 mg/kg/day for 40 days) presented better treatment efficacy than with the standard protocol (100 mg/kg/day for 20 days) although the best result in the treatment of the animals infected by the VL-10 strain was with100 mg/kg/day for 40 days. In the acute infection by the Y and VL-10 strains of T. cruzi, the treatment with a standard dose, but with a longer time of treatment (100 mg/kg/day for 40 days) presented the best results. Given these data, our results indicate that for BNZ, the theory of dose and time proportionality does not apply to the phases of infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available