Journal
ESC HEART FAILURE
Volume 8, Issue 6, Pages 4710-4714Publisher
WILEY PERIODICALS, INC
DOI: 10.1002/ehf2.13613
Keywords
COVID-19; Vaccine; Myocarditis; mRNA-1273
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A case of acute myocarditis following mRNA-1273 vaccination was reported, with the patient showing no history of SARS-CoV-2 infection but exhibiting myocardial inflammation and dysfunction. The strong temporal relation between vaccination and symptom onset suggested a potential side effect of mRNA-1273.
We describe a case of a 20-year-old healthy man developing chest pain and classical symptoms of vaccine reactogenicity 12 h after receiving the first dose of mRNA-1273 (Moderna). Cardiac troponin T was increased, and subepicardial inflammation and focal contractile dysfunction were detected by cardiac magnetic resonance imaging and echocardiography. We confirmed the diagnosis of acute myocarditis by endomyocardial biopsy demonstrating significant infiltration of monocytes and T lymphocytes. Although we detected IgG against nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicating prior infection, the patient repeatedly tested negative for SARS-CoV-2 and had been asymptomatic for several months. Furthermore, viral genome analysis of endomyocardial biopsy samples was negative for SARS-CoV-2 and other potential cardiotropic viruses. These findings and the strong temporal relation between the vaccination and the symptom onset imply a potential side effect of mRNA-1273.
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