Journal
ESC HEART FAILURE
Volume 8, Issue 5, Pages 3577-3586Publisher
WILEY PERIODICALS, INC
DOI: 10.1002/ehf2.13485
Keywords
Cardiorenal syndrome; Creatinine; Cystatin C; Mortality; Quality of life; Shrunken pore
Categories
Funding
- Medical Faculty of Lund University (Medicinska Fakulteten, Lunds Universitet)
- Skane University Hospital (Skanes universitetssjukhus)
- Crafoord Foundation (Crafoordska Stiftelsen)
- Ernhold Lundstrom's Research Foundation (Ernhold Lundstrom Stiftelse)
- Region Skane (HjartLungfonden)
- Hulda and Conrad Mossfelt Foundation (Hulda och E Conrad Mossfelts Stiftelse for Vetenskaplig Forskning Inom Hjart-och Karlsjukdomarnas Omrade)
- Southwest Skane's Diabetes Foundation (Sydvastra Skanes Diabetesforening)
- Kockska Foundation
- Research Funds of Region Skane
- Swedish Heart and Lung Foundation
- Wallenberg Center for Molecular Medicine, Lund University
- Medical Faculty of Lund University
- Swedish Kidney Foundation (Njurfonden)
- Njurstiftelsen
- Skane University Hospital Research Fund
- Research and Development Council of Region Skane (Skane County Council's Research and Development Foundation), Sweden
- Region Skane
- Lund University (Lunds Universitet)
Ask authors/readers for more resources
This study found an association between 'Shrunken pore syndrome' (SPS) and increased risk of death, 30 day rehospitalization, as well as impaired health-related quality of life in heart failure patients.
Aims This study aimed to investigate the association between the 'Shrunken pore syndrome' (SPS) and risk of death, 30 day rehospitalization, and health-related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFR(cystatin C)/eGFR(creatinine) ratio. Methods and results A total of 373 patients hospitalized for HF [mean age 74.8 (+/- 12.1) years; 118 (31.6%) women] were retrieved from the HeARt and brain failure inVESTigation trial (HARVEST-Malmo). Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas were used for estimation of glomerular filtration rate (eGFR). Presence of SPS was defined as eGFR(cystatin C) <= 60% of eGFR(creatinine). In Cox regression multivariate models, associations between SPS, risk of death (median follow-up time 1.8 years), and risk of 30 day rehospitalization were studied. Associations between SPS and impaired QoL were studied using multivariate logistic regressions. In multivariate models, SPS was associated with all-cause mortality [124 events; hazard ratio (HR) 1.99; 95% confidence interval (95% CI) 1.23-3.21; P = 0.005] and with 30 day rehospitalization (70 events; HR 1.82; CI 95% 1.04-3.18; P = 0.036). Analyses of QoL, based on a Kansas City Cardiomyopathy Questionnaire overall score < 50, revealed that SPS was associated with higher risk of low health-related QoL (odds ratios 2.15; CI 95% 1.03-4.49; P = 0.042). Conclusions The results of this observational study show for the first time an association between SPS and poor prognosis in HF. Further studies are needed to confirm the results in HF cohorts and experimental settings to identify pathophysiological mechanisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available