Journal
FRONTIERS IN MOLECULAR BIOSCIENCES
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmolb.2021.625722
Keywords
circular RNAs; exosome; liquid biopsy; non-small cell lung cancer; biomarker
Categories
Funding
- Improvement Project for Theranostic Ability on Difficulty Miscellaneous Disease (Tumor)
- Science and Technology Innovation Fostering Foundation of Zhongnan Hospital of Wuhan University [ZLYNXM202008, znpy2019050, znpy2019004, znpy2018027]
- Medical Top-Talented Youth Development Project of Hubei Province [WJ2019Q049]
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The high incidence and mortality of lung cancer make early detection crucial, with circRNAs playing a critical role in cancer progression and showing potential as specific diagnostic markers for NSCLC. Liquid biopsy, with its high sensitivity and possibility of multiple sampling, is essential in early cancer detection.
The high incidence and mortality of lung cancer make early detection of lung cancer particularly important. At present, the diagnosis of lung cancer mainly depends on diagnostic imaging and tissue biopsy. However, current diagnostics are not satisfactory owing to the low specificity and inability of multiple sampling. Accumulating evidence indicates that circular RNAs (circRNAs) play a critical role in cancer progression and are promising cancer biomarkers. In particular, circRNAs are considered novel specific diagnostic markers for non-small cell lung cancer (NSCLC). Liquid biopsy is an important method in the early diagnosis of cancer due to its high sensitivity and specificity, as well as the possibility of performing multiple sampling. circRNAs are stably present in exosomes and sometimes become part of circulating nucleic acids, making them ideal for liquid biopsy. In this review, we summarize the advances in the research on circRNAs in NSCLC, and also highlight their potential applications for NSCLC detection.
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