Journal
DERMATOLOGY AND THERAPY
Volume 11, Issue 5, Pages 1587-1597Publisher
ADIS INT LTD
DOI: 10.1007/s13555-021-00575-z
Keywords
Melasma; Platelet-rich plasma; Meta-analysis; Systematic review
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Funding
- 1.3.5 Project for Disciplines of Excellence of West China Hospital of Sichuan University
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The systematic evaluation of the efficacy and safety of PRP in treating melasma showed promising results, indicating that PRP alone or in combination with microneedling may be an effective treatment option. Few adverse reactions were reported, supporting the safety profile of PRP use in melasma treatment.
Introduction Melasma is a chronic and recurrent skin problem for which an effective therapy is currently lacking. Platelet-rich plasma (PRP) has recently emerged as a novel treatment for melasma, but to date there has been no systematic evaluation of its efficacy and safety. Methods The Web of Science, PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and the Cochrane Library databases were searched for relevant articles using the search items melasma, chloasma and platelet-rich plasma. STATA version 15.1 software was used to analyze data. Study outcomes were calculated using standardized mean differences with 95% confidence intervals (CIs). Results The database search identified ten studies involving 395 adult patients that met the inclusion criteria and were included in the meta-analysis. Analysis of pre- and post-treatment data from these studies revealed that the post-treatment modified Melasma Area and Severity Index (mMASI) score decreased by 1.18 (95% CI 0.89-1.47; p = 0.02). Subjective satisfaction evaluation of PRP treatment showed that melasma treated with the combination therapy of PRP + microneedling may have been the most efficacious treatment compared to PRP alone or in combination with intradermal injection. Adverse reactions were minor, with only a few patients reporting local congestion, temporary erythema, hyperpigmentation and discoloration. Conclusion These results support the efficacy and safety of PRP used in combination or alone as treatment for melasma.
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