Journal
MICROORGANISMS
Volume 9, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms9061122
Keywords
bile salt hydrolases; bile acids; human health; gut microbiota; holobiont
Categories
Funding
- Microbiology and the Food Chain Division (MICA) of the INRAE Institute, ONIRIS
- Twinning European Project MICAfrica [952583]
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The gut microbiota has been increasingly linked to metabolic health and disease, with bile salt hydrolase (BSH) playing a key role in both microbial and host physiology. Understanding the role of BSH in health can pave the way for new therapeutic targets in human diseases.
The gut microbiota has been increasingly linked to metabolic health and disease over the last few decades. Several factors have been suggested to be involved in lipid metabolism and metabolic responses. One mediator that has gained great interest as a clinically important enzyme is bile salt hydrolase (BSH). BSH enzymes are widely distributed in human gastrointestinal microbial communities and are believed to play key roles in both microbial and host physiology. In this review, we discuss the current evidence related to the role of BSHs in health and provide useful insights that may pave the way for new therapeutic targets in human diseases.
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