Journal
MICROORGANISMS
Volume 9, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/microorganisms9091865
Keywords
Bacillus subtilis; antisense RNA; sRNA; cis-encoded regulatory RNA; trans-encoded sRNA; dual-function sRNA; RNA chaperone; Hfq; CsrA; SR1
Categories
Funding
- DFG (Deutsche Forschungsgemeinschaft) [BR1552/12-1]
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sRNAs act as abundant posttranscriptional regulators in all three kingdoms of life, with various methods being used to study chromosome-encoded sRNAs in bacteria over the past 20 years; while improved bioinformatics tools can predict potential sRNA targets, experimental confirmation remains challenging; known sRNAs in B. subtilis have defined targets and regulatory mechanisms.
Small regulatory RNAs (sRNAs) that act by base-pairing are the most abundant posttranscriptional regulators in all three kingdoms of life. Over the past 20 years, a variety of approaches have been employed to discover chromosome-encoded sRNAs in a multitude of bacterial species. However, although largely improved bioinformatics tools are available to predict potential targets of base-pairing sRNAs, it is still challenging to confirm these targets experimentally and to elucidate the mechanisms as well as the physiological role of their sRNA-mediated regulation. Here, we provide an overview of currently known cis- and trans-encoded sRNAs from B. subtilis with known targets and defined regulatory mechanisms and on the potential role of RNA chaperones that are or might be required to facilitate sRNA regulation in this important Gram-positive model organism.
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