Comparison of SARS-CoV-2 PCR-Based Detection Using Saliva or Nasopharyngeal Swab Specimens in Asymptomatic Populations

Article Microbiology

Saliva Is a Promising Alternative Specimen for the Detection of SARS-CoV-2 in Children and Adults

Rebecca Yee et al.

Summary: Overall concordances for saliva and NPS were 91.0% and 94.7% respectively, with positive percent agreement (PPA) values of 81.4% and 89.7%. Saliva detected 10 additional positive cases compared to NPS. Both saliva and NPS showed comparable performance for symptomatic and asymptomatic pediatric patients not previously diagnosed with COVID-19.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Review Medicine, General & Internal

Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2 A Systematic Review and Meta-analysis

Guillaume Butler-Laporte et al.

Summary: This study evaluated the diagnostic accuracy of saliva NAAT for COVID-19 and found that its accuracy is similar to that of nasopharyngeal swab NAAT, especially in ambulatory settings. This suggests the potential for saliva NAAT as an alternative to nasopharyngeal swabs and supports further research in this area.

JAMA INTERNAL MEDICINE (2021)

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Article Immunology

COVID-19-Lessons Learned and Questions Remaining

Ferric C. Fang et al.

Summary: In this article, the editors of Clinical Infectious Diseases review important lessons learned about the epidemiology, clinical features, diagnosis, treatment and prevention of SARS-CoV-2 infection, and identify essential questions about COVID-19 that remain to be answered.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Infectious Diseases