Journal
ANTIOXIDANTS
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/antiox10091471
Keywords
protein aggregation; inhibition of amyloid fibril formation; polyphenols; curcumin; resveratrol; quercetin; ascorbic acid; vitamin C; synergistic effect of antioxidants; human stefin B; progressive myoclonus epilepsy of type 1-EPM1
Funding
- ARRS [P1-0140]
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The study showed that curcumin and quercetin exhibited synergy with vitC in affecting protein aggregation to amyloid fibrils in in vitro experiments.
In order to study how polyphenols and vitamin C (vitC) together affect protein aggregation to amyloid fibrils, we performed similar in vitro studies as before using stefin B as a model and a potentially amyloid-forming protein (it aggregates upon overexpression, under stressful conditions and some progressive myoclonus epilepsy of tape 1-EPM1-missense mutations). In addition to the chosen polyphenol, this time, we added a proven antioxidant concentration of 0.5 mM vitC into the fibrillation mixture and varied concentrations of resveratrol, quercetin, and curcumin. Synergy with vitC was observed with curcumin and quercetin.
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