4.7 Article

Lipid Peroxidation Assessment in Preclinical Alzheimer Disease Diagnosis

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

Longfei Jia et al.

Summary: This study showed that exosomal GAP43, neurogranin, SNAP25, and synaptotagmin 1 serve as effective biomarkers for predicting AD 5 to 7 years before cognitive impairment.

ALZHEIMERS & DEMENTIA (2021)

Article Biochemistry & Molecular Biology

Preventive and Therapeutic Strategies in Alzheimer's Disease: Focus on Oxidative Stress, Redox Metals, and Ferroptosis

German Plascencia-Villa et al.

Summary: There is currently no effective treatment for neurodegenerative diseases like Alzheimer's disease, with clinical trials focusing on amyloid treatments facing challenges and setbacks. Research is now shifting towards alternative areas such as ApoE, oxidative stress, and neuroinflammation as potential new avenues for therapeutic development.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Article Biochemistry & Molecular Biology

Plasma isoprostanoids assessment as Alzheimer's disease progression biomarkers

Carmen Pena-Bautista et al.

Summary: The study analyzed the utility of lipid peroxidation biomarkers in evaluating Alzheimer's Disease progression, with some analytes showing an increasing trend over time. A regression model developed based on baseline values could predict long-term cognitive status.

JOURNAL OF NEUROCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative

Thomas K. Karikari et al.

Summary: Plasma phosphorylated-tau181 (p-tau181) is a promising blood-based biomarker specific for Alzheimer's disease (AD), showing high diagnostic accuracy and increasing levels with disease progression.

MOLECULAR PSYCHIATRY (2021)

Article Clinical Neurology

Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease

Shorena Janelidze et al.

Summary: This study highlights the potential of plasma P-tau217 as an early biomarker for Alzheimer's disease, showing elevated levels before tau-PET detected insoluble tau aggregates. Modeling suggests that changes in plasma and CSF P-tau217 precede tau-PET signals, indicating its usefulness in detecting early AD brain pathology.

JAMA NEUROLOGY (2021)

Article Psychiatry

Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer's disease

Hao Hu et al.

Summary: The study found that hypomethylation of the BIN1 promoter in peripheral blood is associated with early cognitive decline in late-onset Alzheimer's disease (LOAD). Additionally, changes in methylation levels are correlated with alterations in AD-related biomarkers in cerebrospinal fluid, particularly in participants with significant AD biological characteristics and subjective cognitive decline (SCD).

TRANSLATIONAL PSYCHIATRY (2021)

Article Clinical Neurology

Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70

Ashvini Keshavan et al.

Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.

BRAIN (2021)

Article Clinical Neurology

Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70

Ashvini Keshavan et al.

Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.

BRAIN (2021)

Article Biochemistry & Molecular Biology

Isoprostanoids Levels in Cerebrospinal Fluid Do Not Reflect Alzheimer's Disease

Carmen Pena-Bautista et al.

ANTIOXIDANTS (2020)

Article Biochemistry & Molecular Biology

Clinical Utility of Plasma Lipid Peroxidation Biomarkers in Alzheimer's Disease Differential Diagnosis

Carmen Pena-Bautista et al.

ANTIOXIDANTS (2020)

Article Neurosciences

Plasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer's Disease

Yen Ying Lim et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

Article Clinical Neurology

A panel of blood lipids associated with cognitive performance, brain atrophy, and Alzheimer's diagnosis: A longitudinal study of elders without dementia

Ya-Hui Ma et al.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2020)

Article Biochemical Research Methods

Plasma metabolomics in early Alzheimer's disease patients diagnosed with amyloid biomarker

Carmen Pena-Bautista et al.

JOURNAL OF PROTEOMICS (2019)

Article Geriatrics & Gerontology

Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD

Alden L. Gross et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Medical Laboratory Technology

Lipid peroxidation in neurodegeneration

Carmen Pena-Bautista et al.

CLINICA CHIMICA ACTA (2019)

Article Clinical Neurology

Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease

Emily Eruysal et al.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2019)

Article Biochemistry & Molecular Biology

Plasma lipid peroxidation biomarkers for early and non-invasive Alzheimer Disease detection

Carmen Pena-Bautista et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Clinical Neurology

Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study

Saima Hilal et al.

ALZHEIMERS RESEARCH & THERAPY (2018)

Review Immunology

Alzheimer's disease: A matter of blood-brain barrier dysfunction?

Axel Montagne et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Review Clinical Neurology

Potential oxidative stress biomarkers of mild cognitive impairment due to Alzheimer disease

Ana Garcia-Blanco et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2017)

Article Clinical Neurology

Plasma concentrations of free amyloid β cannot predict the development of Alzheimer's disease

Hugo Lovheim et al.

ALZHEIMERS & DEMENTIA (2017)

Article Clinical Neurology

Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis

Petroula Proitsi et al.

ALZHEIMERS & DEMENTIA (2017)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

LANCET (2016)

Article Clinical Neurology

Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer's Disease

Massimo S. Fiandaca et al.

FRONTIERS IN NEUROLOGY (2015)

Article Biochemistry & Molecular Biology

Plasma phospholipids identify antecedent memory impairment in older adults

Mark Mapstone et al.

NATURE MEDICINE (2014)

Article Pharmacology & Pharmacy

Alzheimers Disease: Pathological Mechanisms and Recent Insights

Dana M. Niedowicz et al.

Current Neuropharmacology (2011)

Article Computer Science, Interdisciplinary Applications

Regularization Paths for Generalized Linear Models via Coordinate Descent

Jerome Friedman et al.

JOURNAL OF STATISTICAL SOFTWARE (2010)