Journal
ANTIOXIDANTS
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/antiox10081252
Keywords
resveratrol; oxyresveratrol; acetylated derivative; matrix metalloproteinase-1; type I collagen; ultraviolet B; skin aging
Funding
- Small and Medium Business Administration in South Korea
Ask authors/readers for more resources
Research has shown that RES, OXYRES, and their acetylated derivatives have enhanced stability and anti-aging effects in cosmetics, inhibiting oxidative discoloration and unpleasant odor. They work by suppressing H2O2-induced ROS levels and inhibiting skin aging through various cellular signaling pathways.
Resveratrol (RES) and oxyresveratrol (OXYRES) are considered and utilized as active ingredients of anti-aging skin cosmetics. However, these compounds are susceptible to oxidative discoloration and unpleasant odor in solutions, limiting their use in cosmetics. Accordingly, RES and OXYRES were chemically modified to acetylated derivatives with enhanced stability, and their anti-aging effect on the skin and detailed molecular mechanism of their acetylated derivatives were investigated. Acetylated RES and OXYRES lost their acetyl group and exerted an inhibitory effect on H2O2-induced ROS levels in human dermal fibroblast (HDF) cells. In addition, RES, OXYRES, and their acetylated derivatives suppressed UVB-induced matrix metalloproteinase (MMP)-1 expression via inhibition of mitogen-activated protein kinases (MAPKs) and Akt/mTOR signaling pathways. Furthermore, RES, OXYRES, and their acetylated derivatives suppressed type I collagen in TPA-treated HDF cells. Collectively, these results suggest the beneficial effects and underlying molecular mechanisms of RES, OXYRES, and their acetylated derivatives for anti- skin aging applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available