Journal
BIOMOLECULES
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biom11081210
Keywords
hyperbaric oxygen therapy; hyperbaric oxygenation; oxidative stress; inflammation; angiogenesis; neovascularization
Categories
Ask authors/readers for more resources
HBOT has potential new treatment applications in preconditioning for surgery, reducing complications rates and hospital stay by reducing inflammation and promoting angiogenesis through oxidative stress modulation. Further research is needed to determine the implications of these findings for clinical practice.
Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inflammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inflammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the first HBOT session or for a short duration after each session. The anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-kappa B and I kappa B alpha. Further research into the effect of HBOT on inflammation and angiogenesis is needed to determine the implications of these findings for clinical practice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available