Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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News Item Medicine, General & Internal

Covid-19: Medical community split over vaccine interval policy as WHO recommends six weeks

Elisabeth Mahase

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal

Covid-19 vaccination: What’s the evidence for extending the dosing interval?

Gareth Iacobucci et al.

BMJ-British Medical Journal (2021)

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Article Immunology

Predictors of COVID-19 vaccine hesitancy in the UK household longitudinal study

Elaine Robertson et al.

Summary: Overall, vaccine hesitancy in the UK is low, but higher in women, younger age groups, and those with lower education levels. Vaccine hesitancy is particularly high in certain ethnic minority groups, calling for urgent action to address the issue.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Public, Environmental & Occupational Health

Vaccine hesitancy in the era of COVID-19

G. Troiano et al.

Summary: During the COVID-19 pandemic, vaccine hesitancy remains a significant issue, with factors such as ethnicity, working status, religiosity, politics, gender, age, education, and income influencing acceptance or refusal. Common reasons for vaccine refusal include concerns about safety, belief in the vaccine's ineffectiveness, lack of trust, doubts about vaccine efficiency, belief in preexisting immunity, and skepticism about the vaccine's origins.

PUBLIC HEALTH (2021)

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Article Public, Environmental & Occupational Health

First Month of COVID-19 Vaccine Safety Monitoring - United States, December 14, 2020-January 13, 2021

Julianne Gee et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Immunology

The Changing Acceptance of COVID-19 Vaccination in Different Epidemic Phases in China: A Longitudinal Study

Jiahao Wang et al.

Summary: Public acceptance for COVID-19 vaccination in China remained high during different epidemic phases, but the intention for immediate vaccination declined significantly due to concerns about vaccine safety. Information about vaccination safety from authoritative sources, doctor's recommendations, and vaccination convenience were important in addressing vaccine hesitancy and promoting successful herd immunity for the general population in China.

VACCINES (2021)

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Article Infectious Diseases

Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021

Massimo Fabiani et al.

Summary: A study conducted in Italy showed that the BioNTech/Pfizer COVID-19 vaccine has an effectiveness of 84% and 95% in preventing SARS-CoV-2 infection within certain time intervals, supporting ongoing vaccination campaigns with targeted communication.

EUROSURVEILLANCE (2021)

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Article Medicine, General & Internal

Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study

Eleftheria Vasileiou et al.

Summary: The study in Scotland found that the first doses of the BNT162b2 mRNA and ChAdOx1 vaccines were associated with substantial reductions in the risk of COVID-19 hospital admission, with vaccine effectiveness ranging from 88% to 91% at 28-34 days post-vaccination.

LANCET (2021)

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Article Medicine, General & Internal

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Eric J. Haas et al.

Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.

LANCET (2021)

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Article Medicine, General & Internal

COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study

Victoria Jane Hall et al.

Summary: The study aimed to determine the factors associated with vaccine coverage for two COVID-19 vaccines in the UK and to document the vaccine effectiveness of the BNT162b2 mRNA vaccine among healthcare workers. Results showed that the vaccine can prevent both symptomatic and asymptomatic infections in working-age adults, with a vaccine effectiveness of 70% after the first dose and 85% after the second dose.

LANCET (2021)

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Article Biochemistry & Molecular Biology

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

Delphine Planas et al.

Summary: The ability of convalescent sera from individuals with coronavirus disease 2019 and those vaccinated with BNT162b2 to neutralize SARS-CoV-2 variants B1.1.7 and B.1.351 decreases, but increases after two vaccine doses. The study found that the B.1.1.7 and B.1.351 variants may have acquired partial resistance to neutralizing antibodies generated by natural infection or vaccination, particularly in individuals with low antibody levels. This suggests that the B.1.351 variant may pose a greater risk of infection in immunized individuals.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

Laith J. Abu-Raddad et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Medicine, General & Internal

New SARS-CoV-2 Variants - Clinical, Public Health, and Vaccine Implications

Salim S. Abdool Karim et al.

Summary: The emergence of SARS-CoV-2 variants, including B.1.1.7 (VOC-202012/01), 501Y.V2 (B.1.351), and P.1 (B.1.1.28.1), has raised concerns about worsening Covid-19 and potential escape from vaccine-induced immunity.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

Leonidas Stamatatos et al.

Summary: The study found that vaccination of both previously infected individuals and those who were not infected resulted in increased neutralizing antibody titers, with previously infected individuals showing a greater boost in neutralizing titers. Vaccination of naive individuals also elicited cross-neutralizing responses, but at lower titers.

SCIENCE (2021)

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News Item Medicine, General & Internal

Covid-19: Risk of cerebral blood clots from disease is 10 times that from vaccination, study finds

Ingrid Torjesen

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Editorial Material Medicine, General & Internal

Delaying the second dose of covid-19 vaccines

Dominic Pimenta et al.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Public, Environmental & Occupational Health

COVID-19 Vaccine Second-Dose Completion and Interval Between First and Second Doses Among Vaccinated Persons - United States, December 14, 2020-February 14, 2021

Jennifer L. Kriss et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Public, Environmental & Occupational Health

Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight US Locations, December 2020-March 2021

Mark G. Thompson et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Article Public, Environmental & Occupational Health

Effects of different types of written vaccination information on COVID-19 vaccine hesitancy in the UK (OCEANS-III) : a randomised controlled trial

Daniel Freeman et al.

Summary: The study aimed to test which types of written information about COVID-19 vaccination might increase vaccine acceptance. Personal benefit information reduced hesitancy in strongly hesitant individuals more than information on collective benefits, demonstrating the importance of addressing individual concerns in vaccine messaging.

LANCET PUBLIC HEALTH (2021)

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Article Immunology

Enhancing COVID-19 Vaccines Acceptance: Results from a Survey on Vaccine Hesitancy in Northern Italy

Chiara Reno et al.

Summary: A survey conducted in January 2021 in Italy revealed that 31.1% of the sample had vaccine hesitancy, primarily influenced by past vaccination refusal and perceived risk of infection. Other significant predictors included age, gender, education level, income, and comorbidities.

VACCINES (2021)

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Review Immunology

Efficacy and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Ali Pormohammad et al.

Summary: This study systematically reviewed the clinical features of COVID-19 vaccines in clinical trials, finding that mRNA-based and adenovirus-vectored vaccines exhibited different efficacy and side effect profiles. Both types of vaccines showed high efficacy after the first and second doses, with mRNA-based vaccines having higher reported side effects.

VACCINES (2021)

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Article Immunology

The COVID-19 Vaccine Is Here-Now Who Is Willing to Get It?

William D. S. Killgore et al.

Summary: A survey of 1017 individuals in the U.S. during the COVID-19 vaccine campaign found that the majority were willing to get vaccinated, but some also expressed fear of the vaccine. Political ideology was identified as the most consistent predictor of willingness to be vaccinated and fear of the vaccine among participants.

VACCINES (2021)

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Article Immunology

Acceptance of COVID-19 Vaccination among Front-Line Health Care Workers: A Nationwide Survey of Emergency Medical Services Personnel from Germany

Andre Nohl et al.

Summary: The study aimed to assess the COVID-19 vaccination acceptance of EMS personnel as front-line health care workers in Germany. Results showed a majority willingness to be vaccinated, with some participants still undecided. The study recommends interventions such as continuing education and awareness campaigns to increase vaccine acceptance among hesitant groups.

VACCINES (2021)

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Article Medicine, General & Internal

Adverse Reactions Following the First Dose of ChAdOx1 nCoV-19 Vaccine and BNT162b2 Vaccine for Healthcare Workers in South Korea

Seongman Bae et al.

Summary: A prospective survey conducted in South Korea on healthcare workers who received the first dose of two COVID-19 vaccines showed a higher rate of adverse reactions in the ChAdOx1 group compared to the BNT162b2 group. Females and younger age groups were more likely to experience vaccine-associated adverse reactions.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Article Health Care Sciences & Services

Attitudes towards vaccines and intention to vaccinate against COVID-19: Implications for public health communications

Elise Paul et al.

Summary: This study identified predictors of negative attitudes towards vaccines and unwillingness to receive a COVID-19 vaccine among UK adults, with low-income groups, those who did not receive a flu vaccine last year, poor adherence to COVID-19 guidelines, female gender, and living with children being the most significant predictors of vaccine refusal. High levels of mistrust in vaccine benefit and concerns about future side effects were the most important determinants of vaccine uncertainty and unwillingness to vaccinate against COVID-19.

LANCET REGIONAL HEALTH-EUROPE (2021)

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Article Multidisciplinary Sciences

Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens

Francesca Bravi et al.

PLOS ONE (2020)

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Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 Lethality Did not Change Over Time in Two Italian Provinces

Maria Elena Flacco et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

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Interim Estimates of COVID-19 Vaccine Effectiveness in a Mass Vaccination Setting: Data from an Italian Province

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