Journal
VACCINES
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/vaccines9080886
Keywords
COVID-19; SARS-CoV-2; non-human primates; pathogenesis; drug discovery; vaccine
Categories
Funding
- Programme Medecine Sciences ENS-PSL fellowship
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SARS-CoV-2 causing COVID-19 emerged from China in December 2019 and quickly spread worldwide, leading to a pandemic with unprecedented impacts on public health and economy. Urgent development of curative treatments and vaccines is needed to address the disease.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19). It emerged from China in December 2019 and rapidly spread across the globe, causing a pandemic with unprecedented impacts on public health and economy. Therefore, there is an urgent need for the development of curative treatments and vaccines. In humans, COVID-19 pathogenesis shows a wide range of symptoms, from asymptomatic to severe pneumonia. Identifying animal models of SARS-CoV-2 infection that reflect the clinical symptoms of COVID-19 is of critical importance. Nonhuman primates (NHPss) correspond to relevant models to assess vaccine and antiviral effectiveness. This review discusses the use of NHPs as models for COVID-19 research, with focus on the pathogenesis of SARS-CoV-2 infection, drug discovery and pre-clinical evaluation of vaccine candidates.
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