Journal
VACCINES
Volume 9, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/vaccines9090947
Keywords
SARS-CoV-2; healthcare workers; COVID-19; vaccine; mRNA vaccine; anti-S-RBD antibodies
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The study evaluated the duration of serological protection among healthcare workers three months after vaccination, with 99% of them still having detectable anti-SARS-CoV-2 antibodies after 90 days of receiving the second vaccine shot. Elderly healthcare workers showed significantly lower levels of protective antibodies compared to younger ones, indicating they may lose immunity earlier than other operators.
The COVID-19 pandemic has led to health, social and economic consequences for public health systems. As a result, the development of safe and effective vaccines, in order to contain the infection quickly became a priority. The first vaccine approved by the Italian Agency for Drugs Authorization (AIFA) was the BNT162b2 mRNA vaccine, developed by BioNTech and Pfizer (Comirnaty). Comirnaty contains a molecule called messenger RNA (mRNA), which is a nucleoside-modified RNA that encodes the SARS-CoV-2 spike glycoprotein. Even if data from phase I suggest that vaccine induced antibodies can persist for up to six months following the second shot of BNT vaccine, data regarding the real duration of immunological protection are lacking. In this study, we aimed to evaluate the duration of serological protection by detecting the presence of anti-S-RBD (receptor-binding domain) antibodies for SARS-CoV-2 among a large group of healthcare workers (HCWs) three months after vaccination. 99% of HCWs had a detectable titre of anti-S SARS-CoV-2 antibodies 90 days after the second vaccine shot. Elderly operators showed significantly lower levels of protective antibodies when compared to the younger ones, thus they could become unprotected earlier than other operators.
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