4.7 Article

The Use of Zwitterionic Methylmethacrylat Coated Silicone Inhibits Bacterial Adhesion and Biofilm Formation of Staphylococcus aureus

Journal

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.686192

Keywords

biomaterials; biofilm; coating; 2-methacryloyloxyethyl phosphorylcholine; bacterial inhibition

Funding

  1. Federal Ministry of Education and Research (BMBF)

Ask authors/readers for more resources

Biofilm-associated infections have become a major problem in the medical field in recent decades, leading to the need for modified anti-microbial implant materials. This study compared modified liquid silicone rubber surfaces with two commonly used TPUs, showing reduced bacterial adhesion and biofilm formation on the new materials, suggesting their potential as promising candidates for implant manufacturing.
In recent decades, biofilm-associated infections have become a major problem in many medical fields, leading to a high burden on patients and enormous costs for the healthcare system. Microbial infestations are caused by opportunistic pathogens which often enter the incision already during implantation. In the subsequently formed biofilm bacteria are protected from the hosts immune system and antibiotic action. Therefore, the development of modified, anti-microbial implant materials displays an indispensable task. Thermoplastic polyurethane (TPU) represents the state-of-the-art material in implant manufacturing. Due to the constantly growing areas of application and the associated necessary adjustments, the optimization of these materials is essential. In the present study, modified liquid silicone rubber (LSR) surfaces were compared with two of the most commonly used TPUs in terms of bacterial colonization and biofilm formation. The tests were conducted with the clinically relevant bacterial strains Staphylococcus aureus and Staphylococcus epidermidis. Crystal violet staining and scanning electron microscopy showed reduced adhesion of bacteria and thus biofilm formation on these new materials, suggesting that the investigated materials are promising candidates for implant manufacturing.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available