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WIP:: A multifunctional protein involved in actin cytoskeleton regulation
IM Antón et al.
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T cells use two directionally distinct pathways for cytokine secretion
M Huse et al.
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Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity
JC Fanzo et al.
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The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation
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T cells and their partners: the chemokine dating agency
Antonella Viola et al.
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Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome
A Cianferoni et al.
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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
G Campi et al.
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Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton
M Barda-Saad et al.
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A single class II myosin modulates T cell motility and stopping, but not synapse formation
J Jacobelli et al.
NATURE IMMUNOLOGY (2004)
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
TR Mempel et al.
NATURE (2004)
Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production
JL Cannon et al.
JOURNAL OF IMMUNOLOGY (2004)
Imaging the single cell dynamics of CD4+ T cell activation by dendritic cells in lymph nodes
MJ Miller et al.
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Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization
MJ Brown et al.
BLOOD (2003)
The immunological synapse balances T cell receptor signaling and degradation
KH Lee et al.
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DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1
T Sanui et al.
BLOOD (2003)
Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization
I Tskvitaria-Fuller et al.
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The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes
M Vicente-Manzanares et al.
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The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse
K Badour et al.
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Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin
CL Humphries et al.
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Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses
JS Orange et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder
CA Wise et al.
HUMAN MOLECULAR GENETICS (2002)
TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/ζ complex
N Blanchard et al.
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The intersectin 2 adaptor links Wiskott Aldrich syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis
MKH McGavin et al.
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ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse
EJ Allenspach et al.
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Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin
J Delon et al.
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Somatic mosaicism in Wiskott-Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism
T Wada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Spontaneous in vivo reversion of an inherited mutation in the Wiskott-Aldrich syndrome
T Ariga et al.
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Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation
DR Ambruso et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
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