Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.665519
Keywords
T lymphocytes; immune-related actinopathies; actin cytoskeleton remodeling; immunological synapse; actin binding proteins; primary immunodeficiencies
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Funding
- WWTF (PrecisePID project) [LS16-060]
- CNRS
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The actin cytoskeleton in T lymphocytes plays a crucial role in controlling key cellular activities like antigen scanning and sensing, and polarized delivery of effector molecules via the immunological synapse. This dynamic cytoskeleton remodeling is orchestrated by a complex program of multiple signaling pathways, involving the coordinated actions of various actin regulatory proteins.
The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is known, the coordinated molecular orchestration of the actin cytoskeleton to guide cellular decisions is still ill defined. T lymphocytes provide a prototypical example of how a complex program of actin cytoskeleton remodeling sustains the spatio-temporal control of key cellular activities, namely antigen scanning and sensing, as well as polarized delivery of effector molecules, via the immunological synapse. We here review the unique knowledge on actin dynamics at the T lymphocyte synapse gained through the study of primary immunodeficiences caused by mutations in genes encoding actin regulatory proteins. Beyond the specific roles of individual actin remodelers, we further develop the view that these operate in a coordinated manner and are an integral part of multiple signaling pathways in T lymphocytes.
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