Developmental Robustness: The Haltere Case in Drosophila

Developmental processes have to be robust but also flexible enough to respond to genetic and environmental variations. Different mechanisms have been described to explain the apparent antagonistic nature of developmental robustness and plasticity. Here, we present a self-sufficient molecular model to explain the development of a particular flight organ that is under the control of the Hox gene Ultrabithorax (Ubx) in the fruit fly Drosophila melanogaster. Our model is based on a candidate RNAi screen and additional genetic analyses that all converge to an autonomous and cofactor-independent mode of action for Ubx. We postulate that this self-sufficient molecular mechanism is possible due to an unusually high expression level of the Hox protein. We propose that high dosage could constitute a so far poorly investigated molecular strategy for allowing Hox proteins to both innovate and stabilize new forms during evolution.

Automated summary

Developmental processes must be robust and flexible to cope with genetic and environmental variations. A self-sufficient molecular model is proposed to explain the development of a specific flight organ in the fruit fly, indicating a potential molecular strategy for Hox proteins to innovate and stabilize new forms during evolution.