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PLOS ONE (2013)
Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer
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ONCOLOGY LETTERS (2013)
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PLOS GENETICS (2013)
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DEVELOPMENT (2012)
Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer
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DEVELOPMENTAL BIOLOGY (2012)
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods
Shigeru Sato et al.
DEVELOPMENTAL BIOLOGY (2012)
Six2 and Wnt Regulate Self-Renewal and Commitment of Nephron Progenitors through Shared Gene Regulatory Networks
Joo-Seop Park et al.
DEVELOPMENTAL CELL (2012)
SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor
Andrew J. Murphy et al.
JOURNAL OF PEDIATRIC SURGERY (2012)
Mutation screening of the EYA1, SIX1, and SIX5 genes in an east asian cohort with branchio-oto-renal syndrome
Shih-Hao Wang et al.
LARYNGOSCOPE (2012)
Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties
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ONCOGENE (2012)
SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation
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Expression of Six1 in luminal breast cancers predicts poor prognosis and promotes increases in tumor initiating cells by activation of extracellular signal-regulated kinase and transforming growth factor-beta signaling pathways
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BREAST CANCER RESEARCH (2012)
Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development
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DEVELOPMENTAL BIOLOGY (2011)
A novel dominant mutation in SIX1, affecting a highly conserved residue, result in only auditory defects in humans
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EUROPEAN JOURNAL OF MEDICAL GENETICS (2011)
Mutation Screening of the EYA1, SIX1, and SIX5 Genes in a Large Cohort of Patients Harboring Branchio-oto-Renal Syndrome Calls into Question the Pathogenic Role of SIX5 Mutations
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HUMAN MUTATION (2011)
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CLINICAL GENETICS (2010)
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Heterozygous mutations in SIX3 and SHH are associated with schizencephaly and further expand the clinical spectrum of holoprosencephaly
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HUMAN GENETICS (2010)
MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers
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ONCOGENE (2010)
Muscleblind1, but Not Dmpk or Six5, Contributes to a Complex Phenotype of Muscular and Motivational Deficits in Mouse Models of Myotonic Dystrophy
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PLOS ONE (2010)
Misexpression of miR-196a induces eye anomaly in Xenopus laevis
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BRAIN RESEARCH BULLETIN (2009)
The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease
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CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4
Binglai Chen et al.
DEVELOPMENTAL BIOLOGY (2009)
The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation
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Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo
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DEVELOPMENTAL BIOLOGY (2009)
Clinical spectrum of SIX3-associated mutations in holoprosencephaly: correlation between genotype, phenotype and function
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JOURNAL OF MEDICAL GENETICS (2009)
DNA-binding and regulation mechanisms of the SIX family of retinal determination proteins
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BIOCHEMISTRY (2008)
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
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Six2 functions redundantly immediately downstream of Hoxa2
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DEVELOPMENT (2008)
Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development
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Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium
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DEVELOPMENTAL BIOLOGY (2008)
Haploinsufficiency of Six3 fails to activate sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly
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DEVELOPMENTAL CELL (2008)
Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice
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DEVELOPMENTAL DYNAMICS (2008)
SIX1 mutation screening in 247 branchio-oto-renal syndrome families: A recurrent missense mutation associated with BOR
Amit Kochhar et al.
HUMAN MUTATION (2008)
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
Yongsu Jeong et al.
NATURE GENETICS (2008)
Repression of Six3 by a corepressor regulates rhodopsin expression
Bramanandam Manavathi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Wnt/β-catenin signaling regulates nephron induction during mouse kidney development
Joo-Seop Park et al.
DEVELOPMENT (2007)
Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects
Hiroki Kobayashi et al.
MECHANISMS OF DEVELOPMENT (2007)
Holoprosencephaly
Christele Dubourg et al.
ORPHANET JOURNAL OF RARE DISEASES (2007)
Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome
Bethan E. Hoskins et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Six3 activation of Pax6 expression is essential for mammalian lens induction and specification
Wei Liu et al.
EMBO JOURNAL (2006)
Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
Michelle Self et al.
EMBO JOURNAL (2006)
Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma
K. T. Ng et al.
BRITISH JOURNAL OF CANCER (2006)
Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis
Yoshiyuki Konishi et al.
BRAIN RESEARCH (2006)
Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1
Dan Zou et al.
DEVELOPMENTAL BIOLOGY (2006)
Expression analysis of SIX3 and SIX6 in human tissues reveals differences in expression and a novel correlation between the expression of SIX3 and the genes encoding isocitrate dehydrogenase and cadherin 18
S Aijaz et al.
GENOMICS (2005)
Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo
R Grifone et al.
DEVELOPMENT (2005)
Gene amplification is a mechanism of SW overexpression in breast cancer
KJ Reichenberger et al.
CANCER RESEARCH (2005)
Myotonia and muscle contractile properties in mice with SIX5 deficiency
KE Personius et al.
MUSCLE & NERVE (2005)
A balance of FGF, BMP and WNT signalling positions the future placode territory in the head
A Litsiou et al.
DEVELOPMENT (2005)
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1
RD Coletta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Direct interaction of geminin and Six3 in eye development
F Del Bene et al.
NATURE (2004)
Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators
YL Yu et al.
NATURE MEDICINE (2004)
Six1 controls patterning of the mouse otic vesicle
H Ozaki et al.
DEVELOPMENT (2004)
Temporal requirement for hedgehog signaling in ventral telencephalic patterning
M Fuccillo et al.
DEVELOPMENT (2004)
Analysis of the developmental SIX6 homeobox gene in patients with anophthalmia/microphthalmia
ME Gallardo et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2004)
Six5 is required for spermatogenic cell survival and spermiogenesis
PS Sarkar et al.
HUMAN MOLECULAR GENETICS (2004)
The transcription factor Six2 activates expression of the Gdnf gene as well as its own promoter
S Brodbeck et al.
MECHANISMS OF DEVELOPMENT (2004)
SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes
RG Ruf et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
X Li et al.
NATURE (2003)
The role of Six1 in mammalian auditory system development
WM Zheng et al.
DEVELOPMENT (2003)
Six1 is required for the early organogenesis of mammalian kidney
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DEVELOPMENT (2003)
Altered myogenesis in Six1-deficient mice
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DEVELOPMENT (2003)
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
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GENES & DEVELOPMENT (2003)
Six3 and Six6 activity is modulated by members of the groucho family
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DEVELOPMENT (2003)
Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene
H Wakimoto et al.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY (2002)
Mutually regulated expression of Pax6 and SW and its implications for the Pax6 haploinsufficient lens phenotype
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
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Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts
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NATURE GENETICS (2000)
Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy
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NATURE GENETICS (2000)
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NUCLEIC ACIDS RESEARCH (2000)
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JOURNAL OF CLINICAL PATHOLOGY (2000)
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